Nanoparticles Loaded with Antibiotics to Treat Tropical Disease

  • Author: ChemistryViews
  • Published: 26 November 2021
  • Copyright: Wiley-VCH GmbH
thumbnail image: Nanoparticles Loaded with Antibiotics to Treat Tropical Disease

Melioidosis is an infectious disease caused by a bacterium called Burkholderia pseudomallei. It can be severe or even fatal and is often difficult to diagnose. The disease is most prevalent in northern Australia and Southeast Asia. It can be challenging to treat due to the bacterium's ability to survive inside host cells, where antibiotics have poor bioavailability.


Tracey A. Newman, Nicholas D. Evans, University of Southampton, UK, and colleagues have developed polymersome (PM) nanoparticles made from poly(ethylene oxide)-polycaprolactone (PEO-PCL) copolymers that can be loaded with antibiotics to promote intracellular uptake. The team incorporated the antibiotics doxycycline or rifampicin into the nanoparticles' core or shell, respectively, by adding them to either the aqueous or the organic phase during the formation of the particles.


The researchers used Burkholderia thailandensis-infected macrophages to test the PM uptake and antibiotic release. They found that loaded PM nanoparticles release antibiotics upon uptake by macrophages and reduce the bacterial burden of the cells. According to researchers, PM-based formulations of antibiotics could warrant development for clinical use.


 

 

Article Views: 2589

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH