Modular Modification of Gold Nanoparticles

  • Author: ChemistryViews
  • Published: 02 July 2011
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of the American Chemical Society/ACS Publications
thumbnail image: Modular Modification of Gold Nanoparticles

Nanocarriers that combine multiple properties in an all-in-one system hold great promise for drug delivery. The absence of technology to assemble such highly functionalized devices has hindered progress in nanomedicine so far.


Geert-Jan Boons and colleagues, University of Georgia, USA, report a versatile approach for surface modification of nanoparticles (NPs) by using three bioorthogonal coupling reactions. NPs were prepared that have a gold core modified with a monolayer of poly(ethylene oxide)-β-poly(ε-caprolactone) (PEO-b-PCL) block polymers. The polymers were modified at the PEO terminus with acylhydrazides, amines, and azides. This allowed the introduction of functional modules through coupling with ketones, isocyanates, or active esters and alkynes, respectively.


The strategy is highly modular and permits many different combinations of surface modules as demonstrated by the team’s proof of principle NP which combined peptides for improving cellular uptake and for lysosomal escape, and a fluorescent label for quantification.


Article Views: 3091

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH