Improved Contrast Agents for MRI

  • Author: David Bradley
  • Published: 24 May 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of Materials Chemistry/RSC Publishing
thumbnail image: Improved Contrast Agents for MRI

Magnetic resonance imaging (MRI) is a powerful medical diagnostic and research tool. To overcome the weak signals inherent to the technique requires chemical agents based on lanthanide elements, such as gadolinium, to improve the image. Unfortunately, there are problems with some powerful contrast agents being excreted too quickly to be useful. Heavy molecules suffer the converse effect of being retained too long.

A team at Zhejiang University, China, has turned to nanoscopic dendritic particles as the delivery agents for the necessary gadolinium ions rather than the small molecule chelating agents commonly used. They have demonstrated that these compounds biodegrade under physiological conditions but not so quickly that this process would preclude an MRI investigation. The polyester dendrimer nanoparticles are retained for almost three times as long as the small molecule contrast agent (Magnevist), but are nevertheless hydrolysed particularly in the presence of esterase enzymes and so are readily excreted.

Article Views: 2596

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH