Imaging of Flowing Blood Cells

  • Author: ChemistryViews
  • Published: 31 May 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Biomedical Optics Express/Optical Society of America
thumbnail image: Imaging of Flowing Blood Cells

Measuring the composition of a patient's blood is often the first step in clinical diagnosis, and is most commonly performed by extracting a blood sample for ex vivo analysis using optical flow cytometry and other biochemical assays. This method lacks the ability to provide real-time monitoring of patients in critical conditions.

Lior Golan, Technion-Israel Institute of Technology, Haifa, Israel, and colleagues demonstrate an optical system that allows noninvasive imaging of blood cells in vivo. Their label-free approach for in vivo flow cytometry of blood uses a compact imaging probe that could be adapted for bedside real-time imaging of patients in clinical settings.
With no fluorescence labeling, they show high resolution imaging of red and white blood cells flowing in the oral mucosa (vessel in the lower lip) of a human volunteer. By analyzing the large data sets obtained by the system, valuable blood parameters could be extracted and used for direct, reliable assessment of patient physiology.

This spectrally encoded flow cytometry (SEFC) offers a new set of tools which could be utilized for a wide range of screening and diagnostics applications, and opens new possibilities in the clinical research and practice.

Article Views: 3687

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH