Barking up the Right Tree

  • Author: David Bradley
  • Published: 29 July 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Tetrahedron Letters/Elsevier
thumbnail image: Barking up the Right Tree

Plants remain one of the most useful sources of novel natural products that reveal themselves to have physiological activity and potential applications in medicine. Researchers at the University of Science, Ho Chi Minh City, Viet Nam, and their colleagues have now isolated and studied two new polyisoprenylated acylphloroglucinols, known as thoreliones A and B, as well as a novel tetracyclic xanthone, oxy-thorelione A, from the bark of the tree Calophyllum thorelii.


The team also identified twelve previously known compounds in this species; all identified using proton nuclear magnetic resonance (NMR) spectroscopy. The team explains that this is the first time a 2,2-dimethyl-3-isopropenylcyclopentyl ring has been found in a natural product.

Tests against standard human tumor cell lines, MCF-7, HeLa, and NCI-H460, revealed moderate cytotoxic activity, which might subsequently be optimized in analogs of the compounds.


Article Views: 1847

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH