New Tool for Heterocycle Functionalization

  • Author: Melania Tesio
  • Published: 16 December 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Nature/Nature Publishing Group
thumbnail image: New Tool for Heterocycle Functionalization

Heterocycles, molecules containing a ring where at least one atom is not a carbon, play important roles in medicinal chemistry as they constitute a wide range of drugs. Yuta Fujiwara, Scripps Research Institute, USA, and colleagues demonstrated that ten different zinc bis(alkanesulphinate) salts can be used as a chemical toolkit to incorporate diverse chemical groups into heterocycles and, thus, generate novel chemical compounds for drug discovery.


Zinc bis(alkanesulphinate) salts reacted at heterocycles’ carbon-hydrogen bonds, transforming them into carbon-carbon bonds by attaching the alkyl group of the salts. This conversion produced novel heterocycles bearing pharmaceutically important groups such as the fluoroalkyl group, required to improve the half-life of drugs. The reaction, moreover, could proceed in different solutes (organic solvents, water, cellular fluids), it did not induce substrate decomposition, and it could be sequentially performed.


Article Views: 2680

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH