Mussels-inspired Gel for Damaged Vessels

  • Author: Melania Tesio
  • Published: 20 December 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Proceedings of the National Academy of Sciences/National Academy of Sciences
thumbnail image: Mussels-inspired Gel for Damaged Vessels

Marine mussels stick to rocks under water flow thanks to proteins rich in 3,4-dihydroxy-L-phenylalanine. This aminoacid, in fact, contains cathecol, a benzene derivative that can strongly adhere to organic and inorganic surfaces.


Christian Kastrup, David H. Koch Institute for Integrated Cancer Research, USA, and colleagues mimicked the adhesiveness of mussels in order to obtain a hydrogel firmly and durably adhering to arterial vessels under physiological blood flow. By combining catechol with alginate, a polysaccharide that forms stable and biocompatible hydrogels, the researchers obtained a compound (pictured) that glued to damaged blood vessels. In doing so, the gel formed a protective barrier between the arterial walls and the blood and stabilized atherosclerotic plaques, lipidic arteries’ thickening whose rupture causes heart attacks and strokes.


Article Views: 2287

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)published by Wiley-VCH