(R)-2-Hydroxyglutarate: A Leukemic Enantiomer

  • Author: Melania Tesio
  • Published: 27 February 2013
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Science/American Association for the Advancement of Science (AAAS)
thumbnail image: (<em>R</em>)-2-Hydroxyglutarate: A Leukemic Enantiomer

Acute myeloid leukemia (AML) is a blood cancer characterized by a hyper proliferation of white blood cells. Mutations in isocitrate dehydrogenases, enzymes converting isocitrate into α-ketoglutarate, often occur in AML patients. Their precise pathogenic role, however, remains elusive.

Julie-Aurore Losman, Dana-Farber Cancer Institute, Boston, USA, and colleagues revealed that the (R)-enantiomer of 2-hydroxyglutarate (HG, pictured) plays a crucial role in the development of the leukemic disease. The compound, abnormally produced by isocitrate dehydrogenases as a consequence of their mutations, accumulates in blood cells and deregulate their proliferation, thus promoting the leukemic transformation. (R)-2-HG effects are, however, reversible, as compounds blocking its production could restore a normal cellular growth. Thus, the pharmacological inhibition of (R)-2-HG production might be a valuable therapeutic intervention against acute myeloid leukemias.

Article Views: 3258

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH