Enzymatic Nanocomplexes Against Alcohol Intoxication

  • Author: Melania Tesio
  • Published: 21 February 2013
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Nature Nanotechnology/Nature Publishing Group
thumbnail image: Enzymatic Nanocomplexes Against Alcohol Intoxication

Artificial complexes among enzymes endowed with synergic or complementary functions are highly desirable as they enhance the efficiency and specificity of enzymatic reactions. Creating such structures remains, however, challenging.

Yang Liu, Nankai University, China, and colleagues developed a new strategy to fulfill this task. The researchers conjugated single-strand DNA molecules to inhibitors of enzymes exerting complementary reactions, such as alcohol oxidase and catalase. The DNA assembly induced the creation of a DNA-inhibitors scaffold which could bind the target enzymes, thereby leading to the formation of double-enzymes complexes. Subsequently, the scientists encapsulated these structures into a thin polymer shell and removed the DNA-inhibitors scaffold. In this way, they obtain robust enzymes nanocomplexes which efficiently reduced blood alcohol levels when administered to intoxicated mice.

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