Grape Extracts Keep Kidneys Healthy

  • Author: Melania Tesio
  • Published: 17 March 2013
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Applied Physiology, Nutrition, and Metabolism/Canadian Science Publishing
thumbnail image: Grape Extracts Keep Kidneys Healthy

In obese individuals, the excessive accumulation of fat impairs the renal function. According to Kamel Charradi and colleagues, Université de Carthage, Tunisia, obesity-induced renal dysfunction can be alleviated using grape skin and seed extracts, a common nutritional supplement consisting of polyphenolics and flavonoids.


The researchers revealed that, during a high fat diet, triglycerides accumulate in renal cells where they promote oxidative stress and a depletion of copper ions. In this way, triglycerides reduce the activity of copper-dependent enzymes, ultimately decreasing the renal function. These phenomena, however, are abrogated when the high fat diet is associated with the consumption of grape seed and skin extracts. As a consequence, these supplements can be used to alleviate renal dysfunction induced by obesity or other diseases.


Article Views: 2412

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)published by Wiley-VCH