Nanoparticles for Broken Hearts

  • Author: Melania Tesio
  • Published: 31 March 2013
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Science Translational Medicine/American Association for the Advancement of Science (AAAS)
thumbnail image: Nanoparticles for Broken Hearts

The interruption of the blood flow to the heart causes the death of cardiac cells. A promising therapy for this pathological condition consists on injecting mesenchymal stem cells in the damaged heart areas as these specialized cells are able to originate and, thus, repair cardiac tissues. The lack of contrast agents to guide and monitor their intracardiac implant, however, limits the efficacy of this approach.


This problem prompted Jesse Jokerst and colleagues, University of Standford, USA, to develop novel stem cells imagining tools. To this end, the scientists produced nanoparticles consisting of three components: SiO2, to perform ultrasounds-based imaging, fluorescein isothiocyanate fluorophores to carry out fluorescent imaging, and free Gd3+, a magnetic resonance contrast agent. Once loaded into mensenchymal stem cells, these nanoparticles enabled the researchers to safely and stably monitor the delivery of stem cells to damaged cardiac tissues using optical, magnetic or ultrasound-based systems.


Article Views: 3336

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH