X-Ray Diffraction of Nanocrystals

  • Author: Veronika Belusa
  • Published: 30 January 2014
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: IJCrJ/International Union of Crystallography (IJCr)
thumbnail image: X-Ray Diffraction of Nanocrystals

X-Ray diffraction patterns have been used to reveal the structures of, e.g., sugar crystals or insulin. However, the technique has its limitations due to the so called phase problem: the data loss when tapping data from a three-dimensional crystal into two-dimensions. By this, the magnitude of the diffraction waves is recorded, but not the phase information. Although the latter would give information on the precise position of the atoms in the crystal and by this simplify the mathematics and allow working with lower resolution data and much smaller crystals.


John Spencer and colleagues, Arizona State University, Tempe, AZ, USA, have demonstrated a numerical simulation to extract 3D data. They combine diffraction patterns from dozens of nanocrystals for a given compound. This allows to obtain the between-the-peak data even if the fundamental building blocks, the unit cells, are incomplete in many of the nanocrystals.


Many compounds, like proteins, are reluctant to form large crystals but can form nanocrystals. Therefore, the authors think that their work offers a powerful approach to crystal structures of hard to crystallize materials like in biomedical and pharmaceutical sciences.


Article Views: 2556

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

1 Comments

Rebecca Barnfield wrote:

x-ray

That was interesting. It discusses how it works.

Wed Mar 05 04:01:48 UTC 2014

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH