Nanodiamonds Against Glaucoma

  • Author: Melania Tesio
  • Published: 22 February 2014
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: ACS Nano/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Nanodiamonds Against Glaucoma

Glaucoma is a severe ocular disease that occurs when the optic nerve is damaged. Although different antiglaucoma drugs exist, patient compliance is a big problem. To overcome this issue, Dean Ho and co-workers, Northwestern University, USA, have developed nanodiamond-based contact lenses capable of delivering the glaucoma drug timolol maleate (TM).

The researchers coated nanodiamonds (ND) with polyethyleneimine and than cross-linked them with N-acetylated chitosan in the presence of timolol maleate. In this way, the scientists obtained ND-based nanogels carrying the therapeutic drug. Subsequently, they embedded these ND-nanogels in a hydrogel (a 2-hydroxyethyl methacrylate matrix) and casted them into contact lenses. As N-acetylated chitosan is an enzyme-cleavable polysaccharide, it can be hydrolyzed by lysozyme, an enzyme present in the lacrimal fluid. Thus, when the TM-loaded ND-based contact lenses were exposed to the lacrimal fluid, the lysozyme degraded the ND-nanogels thereby releasing timolol maleate while leaving the lenses intact.

The novel ND-based contact lenses allow the release of timolol maleate in a controlled and sustained manner, and, consequently, they may improve patient compliance.

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