Amphotericin Derivatives on the Way?

  • Author: Melania Tesio
  • Published: 05 May 2014
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Nature Chemical Biology/Nature Publishing Group
thumbnail image: Amphotericin Derivatives on the Way?

Yeasts are pathogenic microorganisms that may give rise to life-threatening infections. The treatment of these pathological conditions becomes particularly challenging when yeasts acquire a resistance to clinically approved antifungal agents. The natural compound amphotericin B (AmB) kills drug-resistant yeasts but its high toxicity limits its clinical use.

A study by Martin Burke, University of Illinois at Urbana-Champaign, Urbana, USA, and colleagues, may pave the way to the development of less toxic AmB derivatives. The researchers revealed that AmB antifungal activity relies on its ability to form large extracellular aggregates that act as a sponge, extracting ergosterol from yeast cellular membranes. As ergosterol is a lipid that plays an essential role in yeast physiology, its extraction kills the yeasts.
By revealing novel insights into the mechanism of action of AmB, this study may facilitate the development of drugs that are able to kill drug-resistant yeast strains but do not have toxic effects associated with AmB.

Article Views: 2532

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH