A New Way to Treat Hepatitis C

  • Author: Melania Tesio
  • Published: 25 August 2014
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of General Virology/Society for General Microbiology
thumbnail image: A New Way to Treat Hepatitis C

Hepatitis C is a serious disease that can lead to liver failure or liver cancer. The current antiviral drugs block hepatitis C virus (HCV) replication and improve patient outcome, but cause strong side effects and are expensive, thus calling for alternatives.


Mark Douglas, University of Sydney (Westmead Hospital), Australia, and colleagues discovered that HCV replication can be blocked using AM251 (pictured above), a selective antagonist of cannabinoid 1 receptors (CB1). These proteins are present on the surface of liver cells where they regulate the metabolism of lipids. The researchers demonstrated that CB1 inhibition by AM251 reduced the viral replication in vitro by interfering with the synthesis of lipids.

CB1 antagonists may, therefore, represent a novel class of drugs to treat hepatitis C.


 

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