New Drug Delivery System

  • Author: ChemViews
  • Published: 11 July 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: University of Rhode Island
thumbnail image: New Drug Delivery System

Prof. Geoffrey Bothun, Prof. Arijit Bose and Yanjing Chen, University of Rhode Island, developed a new system for the controlled delivery of pharmaceutical drugs. Superparamagnetic iron oxide nanoparticles embed in the shell of a liposome release a model drug by making the shell leaky when heat-activated in an alternating current electromagnetic field operating at radio frequencies.

The rate and extent of the release of a model drug molecule is controlled by varying the nanoparticle loading and the magnetic field strength.

The liposomes self-assemble because portions of the lipids are hydrophilic and others are hydrophobic. When lipids and nanoparticles are mixed in a solvent, water is added and the solvent evaporated, the materials automatically assemble themselves into liposomes.

The concept of loading nanoparticles within a hydrophobic shell to focus the activation is brand new. It works because the leakiness of the shell is ultimately what controls the release of the drugs.

Article Views: 4779

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH