Water-Free Liquid Protein

  • Author: ChemistryViews
  • Published: 24 July 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Nature Chemistry/Nature Publishing Group
thumbnail image: Water-Free Liquid Protein

In contrast to the commonly accepted idea that water molecules are essential for protein structure and function, Stephen Mann and co-workers, University of Bristol, UK, have shown that a solvent-free liquid haem metalloprotein can be formed at room temperature and pressure. To achieve this, they melted surfactant nanoconstructs that contained a single-component, stoichiometric myoglobin-polymer.

The solvent-free proteins displayed near-native structures and were demonstrated to bind gaseous ligands, including O2. The authors attribute this to the presence of 20 units of polyethylene oxide in the anionic polymer surfactant, which dissipate the thermal energy through conformational changes. This is thought to provide a flexible layer similar to that of the entrapped water shell that persists on the surface of proteins in nonpolar solvents.

Article Views: 3454

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission and consult our permisson guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH