Synthesis of Chiral Nanoparticles

  • Author:
  • Published: 07 April 2015
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Advanced Materials/Wiley-VCH
thumbnail image: Synthesis of Chiral Nanoparticles

Yitzhak Mastai, Bar-Ilan University, Ramat-Gan, Israel, and Rafael Muñoz-Espí, Max Planck Institute for Polymer Research, Mainz, Germany, and colleagues have developed a simple method to prepare chiral polymer nanoparticles based on amino acids by miniemulsion polymerization. First, the optically active amino acid monomers were prepared by an Einhorn modification of a Schotten–Baumann reaction. Then, the monomers were dissolved in toluene and polymerized in miniemulsion. The size of the obtained chiral polymer particles ranged from 150 to 260 nm, as determined by dynamic light scattering (DLS).

The team found that the chiral polymer nanoparticles serve as nucleating agents for the enantioselective crystallization of racemic mixtures of amino acids. Isothermal titration calorimetry (ITC) was used to measure the adsorption energy of the enantiomers onto the surface of chiral polymeric nanoparticles and proved their enantiospecificity.

The synthesized chiral nanoparticles are suited for the development of enantioselective processes and also contribute to a better understanding of the chiral recognition on polymer surfaces.


Article Views: 3798

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH