New Carbene Chemistry

  • Author: ChemistryViews
  • Published: 26 October 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Chemical Sciences/RSC
thumbnail image: New Carbene Chemistry

Ulrich Siemeling and colleagues, University of Kassel, Germany, have shown that stable N-heterocyclic carbenes (NHCs) can show strongly enhanced reactivities towards fundamentally important small molecules such as ammonia and carbon monoxide, which is unprecedented for diaminocarbene compounds.

The scientists demonstrate that a ferrocene-based NHC is able to add ammonia, methyl acrylate, tert-butyl isocyanide, and carbon monoxide—reactions typical of (alkyl)(amino)carbenes, but unprecedented for diaminocarbenes. They also show that even the simplest stable diaminocarbene, C(NiPr2)2, adds CO. This reaction provideds a new entry to the important β-lactam ring systems commonly found in antibiotics.

The newly discovered reactivity of diaminocarbenes opens the door to an exciting area of synthetically useful carbene chemistry.


Article Views: 3791

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH