Improved Continuous-Flow Hydroarylation

  • Author: ChemistryViews
  • Published: 02 December 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Advanced Synthesis and Catalysis/Wiley-VCH
thumbnail image: Improved Continuous-Flow Hydroarylation

Advantages of continuous-flow technologies for organic synthesis include facile automation, reproducibility, energy efficiency, precise control of reaction parameters and the restriction of by-product formation often caused by prolonged heating.

Magnus Rueping and co-workers, Aachen University, Germany, report the first simple and efficient continuous-flow method for the hydroarylation of arenes and heteroarenes. The process is suitable for various styrenes and employs the heterogeneous catalyst, amberlyst-15.

The reactions were sequentially introduced into the flow cell and performed several times without having to change the catalyst. A series of 1,1-diarylalkanes was produced in good yields (typically 60-95 %), and scale up of this method was achieved to produce diarylmethanes in multigram quantities.

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