Death by Peroxide for Cancer Cells

  • Author: Adrian Neal
  • Published: 01 February 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: ACS Chemical Biology/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Death by Peroxide for Cancer Cells

Organic peroxides are not the first compounds that spring to mind when developing drugs, and they are often excluded from screening assays because of their perceived instability. Nature provides us with limited examples of biologically active peroxides, including the antimalarial drug artemisinin and the 1,2-dioxolane-containing plakinic acids.


Using these compounds as inspiration for their search for anticancer drugs, William Carroll, Keith Woerpel, and colleagues, New York University, USA, tested different 1,2-dioxolanes for cytotoxicity in 59 cell lines. Cytotoxic compounds often work by inducing programmed cell death (apoptosis), however, drug-resistant tumors can get around this. The most promising candidate in the screening (pictured) acted by a different mechanism known as ferroptosis, an iron-dependent pathway. Many cancer cells have elevated iron levels and this compound, "ferroptosis-inducing peroxide" (FINO2), displayed selective toxicity for cancer cells over non-cancer cells, with one of its enantiomers being particularly selective.


Compounds that act by unusual mechanisms are valuable and the researchers present evidence that FINO2 might work against tumors on which traditional drugs fail. Furthermore, like artemisinin, FINO2 is thermally stable, which suggests that organic peroxides should perhaps not be routinely excluded from screening for new drug candidates.


 

 

ChemPlanner - Discover your Synthesis route

 

Article Views: 2796

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH