Pure, Natural Synthesis

  • Author: David Bradley
  • Published: 08 December 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Organic Letters/ACS Publications
thumbnail image: Pure, Natural Synthesis

The first enantioselective total syntheses of intriguing indole alkaloids (+)-condylocarpine (above), (+)-isocondylocarpine and (+)-tubotaiwine was possible with high enantiomeric purity (greater than 99:1).

The syntheses were possible using (1S,5R)-hexahydro-1,5-methano-1H-azocino[4,3-b]indole-12-one as starting material and proceeded via five or six isolated intermediates. The work offers up new insights into how to modify this compound to make other useful products as well as providing a route to these natural products for medicinal screening for anti-inflammatory and analgesic effect.

Article Views: 2661

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH