Pomegranate to Reduce Osteoarthritis Symptoms

  • Author: Costas Agalou
  • Published: 27 February 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of the Science of Food and Agriculture/Society of Chemical Industry (SCI)
  • Associated Societies: Society of Chemical Industry (SCI), UK
thumbnail image: Pomegranate to Reduce Osteoarthritis Symptoms

In recent years there have been numerous studies revealing the benefits of consuming particular fruits and vegetables due to their potential antioxidant effects. Pomegranate juice has attracted huge scientific interest due to its range of antioxidant contents. Some of these compounds are polyphenols, tannins, and anthocyanins, which are beneficial for the reduction of cardiovascular and cerebrovascular diseases, cancer, diabetes, and osteoarthritis.

Osteoarthritis is a condition caused by damaged tissue, loss of cartilage structure and function, and an imbalance in inflammatory and anti-inflammatory pathways. Chondrocytes respond to physical damage by stopping the production of anabolic factors and by releasing more catabolic enzymes, such as matrix metalloproteinases (MMPs).

Although there is no cure for osteoarthritis, as it is very hard to restore the destroyed cartilage, recent studies have shown a strong correlation between polyphenols and the prevention of osteoarthritis-related musculoskeletal inflammation. Nasrin Ghoochani, Ahvaz Jundishapur University of Medical Sciences, Iran, and colleagues performed the first clinical trial on the effect of pomegranate juice on knee osteoarthritis.

Among the patients that participated, it was found that pomegranate juice could significantly decrease Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score and improve physical function and stiffness, with no significant effect on pain score. It may also stop osteoarthritis progression by a significant decrease in mean serum levels of MMP-13.


Article Views: 2308

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter

Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH