Membrane Modification with Click Chemistry

  • Author: Xin Su
  • Published: 09 March 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of Polymer Science Part A: Polymer Chemistry/John Wiley & Sons
thumbnail image: Membrane Modification with Click Chemistry

Polymeric membranes are one of the mostly widely used separation materials in both laboratory and industry. Surface modification is a common method to engineer polymer-based membranes for specialized applications, but is rather limited when it comes to adding functional units beyond simple molecules.

Using a copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" reaction, Morten Meldal, University of Copenhagen, Denmark, Mariusz Grzelakowski, Applied Biomimetic A/S, Nordborg, Denmark, and colleagues have developed a new strategy to immobilize polymersomes on nanoporous polymeric membrane surfaces. Polymersomes are artificial vesicles made from block copolymers.

The team subjected polyacrylonitrile (PAN) membranes to hydrochloric acid hydrolysis, which produced carboxylate groups on the surface. The carboxylates were then reacted with propargylamine, resulting in the desired alkyne groups for the click reaction. The researchers were able to covalently coat the functionalized PAN membranes with a monolayer of azide-functionalized polymersomes.

Since polymersomes are structurally similar to lipid vesicles, the method may be used to prepare cell membrane mimics. Considering the broad compatibility and simplicity of the CuAAC reaction, this work could also provide a solution for conveniently integrating new functionalities into common membranes.


Article Views: 2775

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH