Hydrogel for Bone Regeneration

  • Author: ChemistryViews.org
  • Published: 20 May 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: ACS Applied Materials and Interfaces/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Hydrogel for Bone Regeneration

Treating large bone defects is often a challenge for medical science. If the defect becomes infected, treatment becomes even more difficult. There have been research efforts to find both materials which enhance bone regeneration and materials with antimicrobial effects. However, there are few studies on substances which combine these two properties.

Malcolm Xing, University of Manitoba, Winnipeg, Canada, Quan Yuan, Sichuan University, Chengdu, China, and colleagues have developed and tested a hydrogel containing nanosilver and nanosilica designed to treat infected bone defects. The team first synthesized a biodegradable crosslinker, poly(amidoamine) (PAA). They copolymerized this crosslinker with poly(ethylene glycol) diacrylate (PEGDA) to fabricate a PEGDA−PAA hydrogel system. The team added nanosilver and nanosilica (nAg/nSiO2) particles to the hydrogel to form the final composite material.

The team characterized the material using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray energy-dispersive spectroscopy (EDS) analysis. The researchers found pore sizes of about 50−100 μm in the composite, suitable for supplying cells with nutrients.

The silver nanoparticles have an antimicrobial effect that helps to combat infections. The researchers tested the material's antibacterial properties in vitro and found that it inhibited the growth of both Gram-positive and Gram-negative bacteria. They also tested the composite as a treatment for infected bone defects in rats. After implanting the material, indicators of ongoing infections decreased significantly, while new bone formation was improved compared to an untreated control group.


Article Views: 2037

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter

Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH