Electrochemically Controlled Calcium Release – Poster Presentation

  • Author: ChemistryViews
  • Published: 23 July 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA

Ferrocene Derivatives for Electrochemically Controlled Calcium Release

Ms Koyel X. Bhattacharyya, Ecole Normale Supérieure, Paris, France

We are interested in temporal and spatial control in cation delivery with minimal perturbation of biological systems. The controlled release of nanoquantities of ions plays a role in many cellular functions, such as insulin release and nerve impulses. The study of these functions requires the ability to monitor and regulate the ion flux externally. Traditional methods of ion flux control use micropipettes, which strongly perturb biological systems and synthesis of BAPTA derivatives.

In order to examine biological properties such as oxidative stress and the vesicular release of neurotransmitters by inducing jumps in the concentration of cation effectors near a living cell, the existing aza-crown ether chemistry must be adapted for aqueous media, requiring the construction of ligands that form a stronger binding pocket for the cations, because water, a fairly strong ligand itself, competes with the ligands already in place, allowing the ions to diffuse into aqueous media at lower ion concentrations.

Here, we investigate the electrochemical control of ion concentrations from a distance, permitting more accurate regulation with minimal perturbation.

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH