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My Early View Articles

British Journal of Clinical Pharmacology

The relationship between sunitinib exposure and both efficacy and toxicity in real‐world patients with renal cell carcinoma and gastrointestinal stromal tumour

Published: 27 May 2020

Author(s): Kim Westerdijk, Stefanie D. Krens, Winette T.A. Graaf, Sasja F. Mulder, Carla M.L. Herpen, Tineke Smilde, Nielka P. Erp, Ingrid M.E. Desar

Aim Sunitinib is an oral tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). Because of the large interpatient pharmacokinetic variability and established exposure‐response and exposure‐toxicity relationships in clinical trial patients, therapeutic drug monitoring (TDM) seems promising for optimizing sunitinib exposure. We aimed to investigate the relationship between sunitinib exposure and treatment outcome in a...

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British Journal of Clinical Pharmacology

Exploration of suitable pharmacodynamic parameters for acarbose bioequivalence evaluation: A series of clinical trials with branded acarbose

Published: 27 May 2020

Author(s): Jie Huang, Wen‐yu Liu, Jing‐jing Yu, Jin‐bo Yang, Min Li, Chan Zou, Cheng‐xian Guo, Xiao‐yan Yang, Shuang Yang, Jin‐lian Xie, Zhi‐jun Huang, Hui Chen, Qi Pei, Guo‐ping Yang

Aims To determine deficiencies in the Food and Drug Administration (FDA)'s guidance for assessing acarbose bioequivalence (BE) and to explore optimal pharmacodynamic (PD) metrics for better evaluation of acarbose BE. Methods Three clinical trials with branded acarbose were conducted in healthy subjects, including a pilot study (Study I, n = 11, 50 and 100 mg), a 2×2 crossover BE study (Study II, n = 36, 100 mg) and a 4×4 Williams study (Study III, n = 16, 50/100/150 mg). Serum glucose...

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Biomedical Chromatography

Phytochemical composition profile and space–time accumulation of secondary metabolites for Dracocephalum moldavica Linn. via UPLC–Q/TOF–MS and HPLC–DAD method

Published: 27 May 2020

Author(s): Chao Wu, Hanze Liu, Xiaojuan Rong, Jiahao Liu, Wenzheng Ding, Xuemei Cheng, Jianguo Xing, Changhong Wang

Abstract The aerial parts of Dracocephalum moldavica L. are extensively used in traditional ethnic medicines in China as a remedy for cardiovascular and cerebrovascular damage. However, the chemical composition and the accumulation of main secondary metabolites of D. moldavica in different natural environments remain unclear. This study aimed to conduct a qualitative and quantitative analysis of the main secondary metabolites to explore the quality variation of D. moldavica in markets. The...

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Journal of Polymer Science

Effect of molecular structure of curing agents on cyclic creep in highly cross‐linked epoxy polymers

Published: 26 May 2020

Author(s): Hyungbum Park, Ingyun Chung, Maenghyo Cho

Abstract Ratcheting behavior of highly–cross‐linked epoxy polymers was investigated considering the effect of molecular structure of curing agents by molecular dynamics simulations. Cyclic loading–unloading simulations at two different frequencies were conducted using atomistic models for epoxies cured by aliphatic and aromatic curing agents, triethylenetetramine (TETA) and diethyltoluenediamine (DETDA), respectively. Different ratcheting strain evolutions, dihedral angle stress accumulations,...

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Journal of Biochemical and Molecular Toxicology

S‐allyl cysteine, an active ingredient of garlic, attenuates acute liver dysfunction induced by lipopolysaccharide/ d‐galactosamine in mouse: Underlying mechanisms

Published: 26 May 2020

Author(s): Ali‐Mohammad Rousta, Seyed‐Mohamad‐Sadegh Mirahmadi, Alireza Shahmohammadi, Samira Ramzi, Tourandokht Baluchnejadmojarad, Mehrdad Roghani

Abstract In the present study, beneficial effect of S‐allyl cysteine (SAC) was evaluated in the lipopolysaccharide/d‐galactosamine (LPS/d‐Gal) model of acute liver injury (ALI). To mimic ALI, LPS and d‐Gal (50 μg/kg and 400 mg/kg, respectively) were intraperitoneally administered and animals received SAC per os (25 or 100 mg/kg/d) for 3 days till 1 hour before LPS/d‐Gal injection. Pretreatment of LPS/d‐Gal group with SAC‐lowered activities of alkaline phosphatase, alanine aminotransferase, and...

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Biotechnology and Bioengineering

Off‐target glycans encountered along the synthetic biology route toward humanized N‐glycans in Pichia pastoris

Published: 26 May 2020

Author(s): Bram Laukens, Pieter P. Jacobs, Katelijne Geysens, Jose Martins, Charlot De Wachter, Paul Ameloot, Willy Morelle, Jurgen Haustraete, Jean‐Christophe Renauld, Bart Samyn, Roland Contreras, Simon Devos, Nico Callewaert

Abstract The glycosylation pathways of several eukaryotic protein expression hosts are being engineered to enable the production of therapeutic glycoproteins with humanized application‐customized glycan structures. In several expression hosts, this has been quite successful, but one caveat is that the new N‐glycan structures inadvertently might be substrates for one or more of the multitude of endogenous glycosyltransferases in such heterologous background. This then results in the formation...

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Greenhouse Gases: Science and Technology

Implementing a second generation CCS facility on a coal fired power station – results of a feasibility study to retrofit SaskPower's Shand power station with CCS

Published: 26 May 2020

Author(s): Stavroula Giannaris, Corwyn Bruce, Brent Jacobs, Wayuta Srisang, Dominika Janowczyk

Abstract In 2018, the International CCS Knowledge Centre (CCS Knowledge Centre) conducted a feasibility study with SaskPower to determine if a business case could be made for a postcombustion, carbon capture retrofit of SaskPower's Shand Power station, a 305‐MW, single‐unit, lignite coal‐fired power station located near Estevan, Saskatchewan. Specifically, Mitsubishi heavy industries’ KM CDR technology was evaluated for this study. While no decision has been made, should SaskPower decide to...

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ChemMedChem

Structure‐Activity Relationships of Butyrophilin 3 Ligands

Published: 26 May 2020

Author(s): Andrew J. Wiemer

Abstract Phosphoantigens (pAgs) are small phosphorus‐containing molecules that stimulate Vγ9Vδ2 T cells with sub‐nanomolar cellular potency. Recent work has revealed that these compounds work through binding to the transmembrane immunoglobulin butyrophilin 3A1 (BTN3A1) within its intracellular B30.2 domain. Engagement of BTN3A1 is critical to the formation of an immune synapse between cells that contain pAgs and the Vγ9Vδ2 T cells. This minireview summarizes the structure‐activity...

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Journal of Food Processing and Preservation

Modeling of fragment formation of parchment coffee beans for rapid heat and mass transfer during fluidization drying

Published: 26 May 2020

Author(s): Chaiwat Rattanamechaiskul, Nittaya Junka

Abstract Fluidization drying technique allows fluidized coffee beans to float, resulting in rapid heat and mass transfer, which have been directly associated with an increase in the moisture gradient, creating bean stress. Bean quality is determined by the degree of bean fragmentation caused by drying, an important standard considered in purchasing and selling. We have modeled the drying process to explain the kinetics of bean fragmentation. Drying temperature affected the drying rate and...

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Journal of Food Processing and Preservation

Quality retention and selective gene expression of Chinese flowering cabbage as affected by atmosphere gas composition

Published: 26 May 2020

Author(s): Xuemei Huang, Xuelian Zhang, Xiaoyang Jiang, Shuisheng Huang, Xuequn Pang, Hongxia Qu, Zhaoqi Zhang

Abstract The aim of this research was to obtain the optimum gas compositions of controlled atmosphere (CA) for Chinese flowering cabbage stored at 10°C and to clarify the molecular mechanism of senescence during storage under two selected CA conditions. Two CA experiments were conducted. The first one was on low O2 (5% and 10%) and high CO2 (5% and 10%) combinations, and the second one was on air O2 (20.4%) and high CO2 (5%, 10%, 15%, 30%, and 45%) combinations. It was shown that CA2 (5%...

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Most-accessed articles from each Chemistry Europe, ACES, and GDCh journal

January 2020

 


Hendrik Naatz, Bella B. Manshian, Carla Rios Luci, Vasiliki Tsikourkitoudi, Yiannis Deligiannakis, Johannes Birkenstock, Suman Pokhrel, Lutz Mädler, Stefaan J. Soenen
Model-Based Nanoengineered Pharmacokinetics of Iron-Doped Copper Oxide for Nanomedical Applications [Research Article]
Angew. Chem. Int. Ed. 2020, vol. 59, no. 5, p. 1828

Marc-André Kasper, Marcus Gerlach, Anselm F. L. Schneider, Christiane Groneberg, Philipp Ochtrop, Stefanie Boldt, Dominik Schumacher, Jonas Helma, Heinrich Leonhardt, Mathias Christmann, Christian P. R. Hackenberger
N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates [Full Paper]
ChemBioChem 2020, vol. 21, no. 1-2, p. 113

Michael Bowker
Methanol Synthesis from CO2 Hydrogenation [Minireview]
ChemCatChem 2019, vol. 11, no. 17, p. 4238

V. N. Danilevich, L. E. Petrovskaya, E. V. Grishin
A Highly Efficient Procedure for the Extraction of Soluble Proteins from Bacterial Cells with Mild Chaotropic Solutions [Research Article]
Chem. Eng. Technol. 2008, vol. 31, no. 6, p. 904

Dieter Wöhrle
Kunststoffe [Artikel]
Chem. Unserer Zeit 2019, vol. 53, no. 1, p. 50

Balaram Mukhopadhyay, Rituparna Das
Chemical O-Glycosylations: An Overview [Review]
ChemistryOpen 2016, vol. 5, no. 5, p. 401

Daewoo Han, Andrew J. Steckl
Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications [Review]
ChemPlusChem 2019, vol. 84, no. 10, p. 1453

Miaofang Chi, Harry M. Meyer, Zili Wu, Liangbo Liang, Peter V. Bonnesen, Dale K. Hensley, Rui Peng, Yang Song, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone
High-Selectivity Electrochemical Conversion of CO2 to Ethanol using a Copper Nanoparticle/N-Doped Graphene Electrode [Full Paper]
ChemistrySelect 2016, vol. 1, no. 19, p. 6055

Rüdiger-A. Eichel, Walter Leitner, Kurt Wagemann
Warum wir uns mit Power-to-X beschäftigen [Editorial]
Chem. Ing. Tech. 2020, vol. 92, no. 1-2, p. 3

Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh
Bioethylene Production from Ethanol: A Review and Techno-economical Evaluation [Review]
ChemBioEng Rev. 2017, vol. 4, no. 2, p. 75

Gerhard Hilt
Basic Strategies and Types of Applications in Organic Electrochemistry [Concept]
ChemElectroChem 2020, vol. 7, no. 2, p. 395

Claire M. Cobley
Introducing our Inaugural Early Career Advisory Board [Editorial]
ChemNanoMat 2020, vol. 6, no. 1, p. 4

Felix Blei, Sebastian Dörner, Janis Fricke, Florian Baldeweg, Felix Trottmann, Anna Komor, Florian Meyer, Christian Hertweck, Dirk Hoffmeister
Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms [Full Paper]
Chem. Eur. J. 2020, vol. 26, no. 3, p. 729

Sandip G. Agalave, Suleman R. Maujan, Vandana S. Pore
Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [Focus Review]
Chem. Asian J. 2011, vol. 6, no. 10, p. 2696

Arun K. Sinha, Danish Equbal
Thiol−Ene Reaction: Synthetic Aspects and Mechanistic Studies of an Anti-Markovnikov-Selective Hydrothiolation of Olefins [Focus Review]
Asian J. Org. Chem. 2019, vol. 8, no. 1, p. 32

Thomas H. Pillow, Pragya Adhikari, Robert A. Blake, Jinhua Chen, Geoffrey Del Rosario, Gauri Deshmukh, Isabel Figueroa, Karen E. Gascoigne, Amrita V. Kamath, Susan Kaufman, Tracy Kleinheinz, Katherine R. Kozak, Brandon Latifi, Douglas D. Leipold, Chun Sing Li, Ruina Li, Melinda M. Mulvihill, Aimee O'Donohue, Rebecca K. Rowntree, Jack D. Sadowsky, John Wai, Xinxin Wang, Cong Wu, Zijin Xu, Hui Yao, Shang-Fan Yu, Donglu Zhang, Richard Zang, Hongyan Zhang, Hao Zhou, Xiaoyu Zhu, Peter S. Dragovich
Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity [Full Paper]
ChemMedChem 2020, vol. 15, no. 1, p. 17

Vitali Tugarinov, Theodoros K. Karamanos, Alberto Ceccon, G. Marius Clore
Optimized NMR Experiments for the Isolation of I=1/2 Manifold Transitions in Methyl Groups of Proteins [Communication]
ChemPhysChem 2020, vol. 21, no. 1, p. 13

Hiroki Tanaka, Yoshihisa Inoue, Tadashi Mori
Circularly Polarized Luminescence and Circular Dichroisms in Small Organic Molecules: Correlation between Excitation and Emission Dissymmetry Factors [Review]
ChemPhotoChem 2018, vol. 2, no. 5, p. 386

Kassem Beydoun, Jürgen Klankermayer
Efficient Plastic Waste Recycling to Value-Added Products by Integrated Biomass Processing [Communication]
ChemSusChem 2020, vol. 13, no. 3, p. 488

Stephen A. Matlin, Goverdhan Mehta, Henning Hopf, Alain Krief
The Periodic Table of the Chemical Elements and Sustainable Development [Essay]
Eur. J. Inorg. Chem. 2019, p. 4170

Luca Capaldo, Davide Ravelli
Hydrogen Atom Transfer (HAT): A Versatile Strategy for Substrate Activation in Photocatalyzed Organic Synthesis [Microreview]
Eur. J. Org. Chem. 2017, p. 2056

Cover Picture Lebensmittelchemie 6/2019 [Cover Picture]
Lebensmittelchemie 2019, vol. 73, no. 6

Christian Hering-Junghans, Christian Sindlinger
Trendbericht Anorganische Chemie: Hauptgruppen [Wissenschaft + Forschung]
Nachr. Chem. 2020, vol. 68, no. 1, p. 50

Jana Novotny, Corina Wagner, Marco Oetken
Titelbild: Elektrochemisch aktive Polymere am Beispiel Polypyrrol: Modellsystem einer künstlichen Synapse Ein elektrochemischer Alleskönner - Teil 2 (CHEMKON 8/2019) [Titelbild]
CHEMKON 2019, vol. 26, no. 8, p. 331

Meng Cheng, Ramasubramonian Deivanayagam, Reza Shahbazian-Yassar
3D Printing of Electrochemical Energy Storage Devices: A Review of Printing Techniques and Electrode/Electrolyte Architectures [Review]
Batteries & Supercaps 2020, vol. 3, no. 2, p. 130

Catharina Goedecke
Why Does Iodine Turn Starch Blue?
ChemViews Magazine 2016

Most cited articles from Chemistry Europe, ACES, and GDCh journals


Articles on this list are the most frequently cited ones among those published in 2017 or 2018 according to Web of Science. They have contributed the most to the journal's impact factor in 2019.

 


Yuanjun Chen, Shufang Ji, Yanggang Wang, Juncai Dong, Wenxing Chen, Zhi Li, Rongan Shen, Lirong Zheng, Zhongbin Zhuang, Dingsheng Wang, Yadong Li
Isolated Single Iron Atoms Anchored on N-Doped Porous Carbon as an Efficient Electrocatalyst for the Oxygen Reduction Reaction [Communication]
Angew. Chem. Int. Ed. 2017, vol. 56, pp. 6937–6941

Lik Hang Yuen, Raphael M. Franzini
Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View [Minireview]
ChemBioChem 2017, vol. 18, pp. 829–836

Konstantinos C. Christoforidis, Paolo Fornasiero
Photocatalytic Hydrogen Production: A Rift into the Future Energy Supply [Review]
ChemCatChem 2017, vol. 9, pp. 1523–1544

Massimo Baroncini, Lorenzo Casimiro, Christiaan de Vet, Jessica Groppi, Serena Silvi, Alberto Credi
Making and Operating Molecular Machines: A Multidisciplinary Challenge [Minireview]
ChemistryOpen 2018, vol. 7, pp. 169–179

Hanshen Xin, Xike Gao
Application of Azulene in Constructing Organic Optoelectronic Materials: New Tricks for an Old Dog [Minireview]
ChemPlusChem 2017, vol. 82, pp. 945–956

Hojat Veisi, Mozhgan Pirhayati, Ali Kakanejadifard, Pourya Mohammadi, Mohammad Reza Abdi, Javad Gholami, Saba Hemmati
In Situ Green Synthesis of Pd Nanoparticles on Tannic Acid-Modified Magnetite Nanoparticles as a Green Reductant and Stabilizer Agent: Its Application as a Recyclable Nanocatalyst (Fe3O4@TA/Pd) for Reduction of 4-Nitrophenol and Suzuki Reactions [Full Paper]
ChemistrySelect 2018, vol. 3, pp. 1820–1826

Tingting Liu, Lisi Xie, Jianhui Yang, Rongmei Kong, Gu Du, Abdullah M. Asiri, Xuping Sun, Liang Chen
Self-Standing CoP Nanosheets Array: A Three-Dimensional Bifunctional Catalyst Electrode for Overall Water Splitting in both Neutral and Alkaline Media [Communication]
ChemElectroChem 2017, vol. 4, pp. 1840–1845

Ruibin Wang, Liheng Chen, J.Y. Zhu, Rendang Yang
Tailored and Integrated Production of Carboxylated Cellulose Nanocrystals (CNC) with Nanofibrils (CNF) through Maleic Acid Hydrolysis [Full Paper]
ChemNanoMat 2017, vol. 3, pp. 328–335

Chengwei Liu, Michal Szostak
Twisted Amides: From Obscurity to Broadly Useful Transition-Metal-Catalyzed Reactions by N−C Amide Bond Activation [Minireview]
Chem. Eur. J. 2017, vol. 23, pp. 7157–7173

Jian Shu, Dianping Tang
Current Advances in Quantum-Dots-Based Photoelectrochemical Immunoassays [Focus Review]
Chem. Asian J. 2017, vol. 12, pp. 2780–2789

Jian Rong, Chuanfa Ni, Jinbo Hu
Metal-Catalyzed Direct Difluoromethylation Reactions [Focus Review]
Asian J. Org. Chem. 2017, vol. 6, pp. 139–152

Juan Alberto Sirvent, Ulrich Lücking
Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates [Full Paper]
ChemMedChem 2017, vol. 12, pp. 487–501

Grzegorz Greczynski, Lars Hultman
C 1s Peak of Adventitious Carbon Aligns to the Vacuum Level: Dire Consequences for Material's Bonding Assignment by Photoelectron Spectroscopy [Communication]
ChemPhysChem 2017, vol. 18, pp. 1507–1512

Jia-Rong Chen, Dong-Mei Yan, Qiang Wei, Wen-Jing Xiao
Photocascade Catalysis: A New Strategy for Cascade Reactions [Concept]
ChemPhotoChem 2017, vol. 1, pp. 148–158

Zhiming Pan, Yun Zheng, Fangsong Guo, Pingping Niu, Xinchen Wang
Decorating CoP and Pt Nanoparticles on Graphitic Carbon Nitride Nanosheets to Promote Overall Water Splitting by Conjugated Polymers [Communication]
ChemSusChem 2017, vol. 10, pp. 87–90

Enzo Alessio
Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective [Microreview]
Eur. J. Inorg. Chem. 2017, pp. 1549–1560

Marcel Garbe, Kathrin Junge, Matthias Beller
Homogeneous Catalysis by Manganese-Based Pincer Complexes [Microreview]
Eur. J. Org. Chem. 2017, pp. 4344–4362

Qian Sun, Kah Chun Lau, Dongsheng Geng, Xiangbo Meng
Atomic and Molecular Layer Deposition for Superior Lithium-Sulfur Batteries: Strategies, Performance, and Mechanisms [Review]
Batteries Supercaps 2018, vol. 1, pp. 41–68

Hojat Veisi, Mozhgan Pirhayati, Ali Kakanejadifard, Pourya Mohammadi, Mohammad Reza Abdi, Javad Gholami, Saba Hemmati
In Situ Green Synthesis of Pd Nanoparticles on Tannic Acid-Modified Magnetite Nanoparticles as a Green Reductant and Stabilizer Agent: Its Application as a Recyclable Nanocatalyst (Fe3O4@TA/Pd) for Reduction of 4-Nitrophenol and Suzuki Reactions [Full Paper]
ChemistrySelect 2018, vol. 3, pp. 1820–1826

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Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH