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Impact Factor: 3.046
A journal of
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Dear Scientist,
ChemMedChem is a leading journal in the field of medicinal chemistry, publishing primary research results in the form of both Full Papers and Communications, as well as key secondary and tertiary contributions such as Reviews, Concepts and Highlights. Articles are published with quality and speed in mind. A decision is typically reached within 19 days of submission, and online publication usually follows receipt of the final version within around 28 days.
To showcase the journal's excellent content, we are giving you free access to ChemMedChem's top 24 most-accessed articles of the last 12 months.
The broad scope of the journal is reflected in the diverse topics covered by the articles: from traditional small molecules and structure–activity relationship studies to peptidomimetics and the application of computational chemistry in drug design. The articles come from a wide range of researchers in all areas of drug discovery and development from around the world–an indication of the journal's global reach and broad scope.
We hope you enjoy browsing the articles and that you will consider submitting your next manuscript to ChemMedChem.
Dr. Natalia Ortúzar
Editor-in-Chief
ChemMedChem
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24 Most Accessed Articles from ChemMedChem:
 Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis
Lluís Ballell, Robert H. Bates, Rob J. Young, et al.
 Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
Stefan Peukert, Karen Miller-Moslin
Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase
Zhengying Pan, Heleen Scheerens, Shyr-Jiann Li, et al.
Prodrug Strategies in Anticancer Chemotherapy
Felix Kratz, Ivonne A. Müller, Claudia Ryppa, André Warnecke
Carboxylic Acid (Bio)Isosteres in Drug Design
Carlo Ballatore, Donna M. Huryn, Amos B. Smith
Thiadiazole–a Promising Structure in Medicinal Chemistry
Yijing Li, Jingkun Geng, Yang Liu, Shenghui Yu, Guisen Zhao
Bromodomains and Their Pharmacological Inhibitors
Daniel Gallenkamp, Kathy A. Gelato, Bernard Haendler, Hilmar Weinmann
Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
Martin Morgenthaler, Eliane Schweizer, Anja Hoffmann-Röder, et al.
Drugs for Hepatitis C: Unlocking a New Mechanism of Action
Thomas W. Bell
Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases
Ruth Brenk, Alessandro Schipani, Daniel James, Agata Krasowski,
Ian Hugh Gilbert, Julie Frearson, Paul Graham Wyatt
Tailoring Small Molecules for an Allosteric Site on Procaspase-6
Jeremy Murray, Anthony M. Giannetti, Micah Steffek, et al.
G-Quadruplexes: Targets in Anticancer Drug Design
Tian-miao Ou, Yu-jing Lu, Jia-heng Tan, Zhi-shu Huang, Kwok-Yin Wong, Lian-quan Gu
Drug Discovery Alliances in India–Indications, Targets, and New Chemical Entities
Edmond Differding
The 7 TM G-Protein-Coupled Receptor Target Family
Edgar Jacoby, Rochdi Bouhelal, Marc Gerspacher, Klaus Seuwen
Hedgehog Pathway Agonism: Therapeutic Potential and Small-Molecule Development
M. Kyle Hadden
Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)
L. W. Lawrence Woo, Dharshini Ganeshapillai, Mark P. Thomas, et al.
Targeting Epigenetics in Drug Discovery
Antonello Mai
Development of Specific "Drug-Like Property" Rules for Carboxylate-Containing Oral Drug Candidates
Alexander Böcker, Pierre R. Bonneau, Oliver Hucke, Araz Jakalian,
Paul J. Edwards
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
Daniel Spinks, Leah S. Torrie, Stephen Thompson, et al.
Synthesis and Biological Evaluation of Benzo[b]furans as Inhibitors of Tubulin Polymerization and Inducers of Apoptosis
Ahmed Kamal, N. V. Subba Reddy, V. Lakshma Nayak, et al.
Runaway ROS as a Selective Anticancer Strategy
Elizabeth I. Parkinson, Paul J. Hergenrother
Revealing Atropisomer Axial Chirality in Drug Discovery
Steven R. LaPlante, Paul J. Edwards, Lee D. Fader, Araz Jakalian, Oliver Hucke
Structure-Based and Fragment-Based GPCR Drug Discovery
Stephen P. Andrews, Giles A. Brown, John A. Christopher
The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors
Astrid Spannhoff, Alexander-Thomas Hauser, Ralf Heinke, Wolfgang Sippl, Manfred Jung
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