Nachrichten aus der Chemie (the membership magazine of the GDCh) annually publishes trend reports in which authors spot and compile an overview of inspiring work and recent trends in the most important chemical disciplines.

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Trends in Biochemistry 2012

C. Hackenberger, O. Reimann, D. Summerer, M. J. Schmidt, M. Helm, S. Kellner

• Synthetic kiss of death: Chemical access to ubiquitinated proteins
• Expansion of the genetic code
• Mass spectrometry of modified nucleic acids

► Full article (in German):

• Trendbericht Biochemie 2012,
  C. Hackenberger, O. Reimann, D. Summerer, M. J. Schmidt, M. Helm, S. Kellner,
  Nachrichten aus der Chemie 2013, 61(3), 298–312.
  DOI: 10.1002/nadc.201390088
  

► All 2012 trend reports on ChemViews

Authors

Christian Hackenberger, born 1976, is in a working group whose focus lies on the development of new chemoselective processes for the recovery of modified functional proteins. He is coordinator of the Schwerpunktprogramms 1623 (Priority Program 1623) with this thematic focus (www.spp1623.de). At the end of 2012 he was appointed to the Leibniz Humboldt Professorship of Chemical Biology at the Leibniz Institute for Molecular Pharmacology (FMP) in Berlin and the Humboldt University Berlin, Germany.

 

Oliver Reimann, born 1984, studied chemistry at the Freie University, Berlin, Germany, and received his Ph.D. from there in 2011 under the supervision of Christian Hackenberger. In his doctoral thesis, supported by the Fonds der Chemischen Industrie, he worked on post-translational variants of Alzheimer-related tau proteins.

 

Daniel Summerer, born 1975, studied chemistry in Bonn, Germany, and gained his Ph.D. from there on the chemical biology of DNA polymerases. After postdoctoral research at the Scripps Research Institute, La Jolla, USA, where he worked in the group of Peter G. Schultz on the expansion of the genetic code, he worked in management positions in the biotech industry in Genomics and Next-Generation Sequencing in Heidelberg, Germany, and Boston, MA, USA. Since 2010 he has been Group Leader of the future program at the University of Konstanz, Germany.

His area of ​​research is in synthetic biology of functional protein-nucleic acid complexes.

 

Moritz J. Schmidt, born 1986, studied life sciences with emphasis on chemistry at the University of Konstanz, Germany. He gained his Ph.D. in 2012 under the supervision of Daniel Summerer as part of the fast track scholarship program of the Chemical Biology Research School, University of Konstanz.

His research interests are in the areas of expansion of the genetic code, RNA recognition, and evolutionary strategies of molecular design.

 

Mark Helm, born 1969, has been a Professor of Pharmaceutical/Medicinal Chemistry at the University of Mainz, Germany, since 2009. He received his Ph.D. in 1999 in molecular biology at the University of Strasbourg, France, after which he undertook postdoctoral research at the California Institute of Technology, USA, and at the Freie Universität Berlin, Germany. After that, he became a Senior Research Scientist in the Department of Chemistry at the Institute of Pharmacy and Molecular Biotechnology of the University of Heidelberg, Germany, where he obtained his Habilitation in 2008 in the fields of pharmaceutical chemistry and biochemistry.

His research interests include ribonucleotide modification, the structural dynamics of RNA molecules, the uptake and intracellular distribution of siRNA, and RNA bioconjugates.

Stefanie Kellner, born 1984, studied pharmacy in Heidelberg, Germany. She subsequently joined the group of Mark Helm, University of Mainz, Germany, working on the functionalization and detection of RNA and its modifications.

Currently she is engaged in the mass spectrometric analysis and quantification of modified nucleic acids.

 

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