Non-Invasive Detection of Bladder Cancer

  • Author: Lisa-Marie Rauschendorfer
  • Published: 30 September 2017
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Advanced Healthcare Materials/Wiley-VCH
thumbnail image: Non-Invasive Detection of Bladder Cancer

The most common symptom of bladder cancer is hematuria (blood in the urine). In order to rule out bladder cancer, if blood is found in the urine, cystoscopy and urinary tract imaging are recommended for all patients. However, only 10 to 30 % of patients are diagnosed with bladder cancer after a full evaluation. Hence, a large number of patients unnecessarily undergo an invasive and expensive procedure.


Steven R. Little, University of Pittsburgh, PA, USA, and colleagues have developed a non-invasive clinical assay to detect bladder cancer. The team uses matrix metalloproteases (MMPs) as a target for their test. These zinc-dependent proteolytic enzymes degrade the extracellular matrix of cells and are significantly increased in the urine of patients with bladder cancer.


The team's test for MMPs uses a substrate (pictured) which is generated by cross-linking gelatin with Fe(II)-chelated alginate nanoparticles, which precipitate in the urine samples. The cleavage of the gelatin-conjugated alginate nanoparticles by MMPs generates free-floating alginate/Fe(II) nanoparticles. These free particles can participate in Fenton's reaction and generate a color shift from purple to yellow. In a trial, the essay was shown to be 100 % sensitive and 85 % specific. It has a negative predictive value of 100 % for diagnosing bladder cancer.


 

Article Views: 613

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH