Why Do the Well-fed Die Young?

  • Author: Margo I. Adler, BioEssays
  • Published: 13 March 2014
  • Source/Publisher: BioEssays/Wiley
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA

The journal Bioessays regularly publishes video abstracts of their articles. Especially outstanding is this example where Margo I. Adler, University of New South Wales, Sydney, Australia, describes a new evolutionary hypothesis for the effect of dietary restriction on lifespan.

Dietary restriction adaptively up-regulates cellular recycling mechanisms like autophagy, a self-degradative process of the cell, and apoptosis, the process of programmed cell death. This increases resource efficiency and promotes immediate reproduction. Old-age pathologies, such as cancer, are reduced as a side effect and this extends the lifespan in laboratory environments.


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