We describe herein a series of intricate trispirocyclic architectures that have been synthesized from readily available substrates through an operationally simple one-pot transformation under mild conditions.

[Research Article]
Manon Genet, Jérôme Marrot, Isabelle Chataigner, Xavier Moreau
ChemistryEurope, https://doi.org/10.1002/ceur.202500362. Read article.

De novo α-SF5-β2,3-amino esters are now accessible through a straightforward aza-Michael reaction using a series of newly developed (E)-α-SF5-α,β-unsaturated esters. Two new, highly functionalized, contiguous tertiary stereocenters are formed with diastereodivergence governed by the choice of solvent and/or base. The syn isomers show high stability, whereas the anti isomers are prone to decomposition. These linear scaffolds, featuring an SF5 group directly attached to the amino ester backbone, represent a significant structural innovation. The approach expands the chemical space, providing access to novel peptide-like fluorinated frameworks suitable for biological evaluation.

[Research Article]
Thi Mo Nguyen, Guilhem Colomer, Oscar Maugue-Sauze, Nicolas Blanchard, Vincent Bizet, Dominique Cahard
ChemistryEurope, https://doi.org/10.1002/ceur.202500255. Read article.

In summary, a visible light-driven redox coupling system is developed. As a trifunctional promoter, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) facilitates both the 1,2,3,4-tetrahydroisoquinoline (THIQ) oxidation by promoting the departure of electron/proton and the CO2 reduction by forming [DBUH]+[THIQ-CO2]-. This dual-promoting effect ensures redox-balanced conversion and enables preparation of high-value products.

[Research Article]
Xiangyang Yao, Wen-Jun Xie, Liqi Qiu, Liang-Nian He
ChemSusChem, https://doi.org/10.1002/cssc.202501750. Read article.

This review systematically summarizes product categories of electrocatalytic CO2 reduction from C1 to C2+ compounds, highlights strategies for steering selectivity toward ethylene/ethanol and C3 products. Moreover, it discusses methods to enhance efficiency, including suppressing hydrogen evolution, catalyst design, electrolyte effects, and reactor integration. Key challenges and techno-economic barriers are finally outlined.

[Review]
Xingqun Li, Junjie Yuan, Zhongqiu Wu, Han Zhang, Yong Li, Quan Zhang, Hui Xu
ChemSusChem, https://doi.org/10.1002/cssc.202501842. Read article.

The Front Cover presents polymorphic zinc-bound amyloid-β (Aβ) dimer models, derived from an extensive computational study of the molecular basis of zinc-induced Aβ primary nucleation. By revealing how zinc ions influence Aβ dimer structure and stability, the Research Article by K. Abramov Harpaz and Y. Miller (DOI: 10.1002/ejic.202500331) provides new insights into the mechanisms driving early aggregation events in Alzheimer’s disease, offering a molecular framework for future therapeutic strategies.

[Cover]
Karina Abramov Harpaz, Yifat Miller
European Journal of Inorganic Chemistry 2025, 0. Read article.

The Front Cover shows a microfluidic chip that was used in an enzyme engineering approach utilizing microdroplet-based UHTS to optimize an aldehyde dehydrogenase towards higher temperature stability and solvent tolerance. The optimized enzyme was then applied as part of a multi-enzyme cascade as indicated by the circle of enzyme structures above the chip. The ultimate goal is a continuous process for the conversion of glucose into isobutanol in a two-phase system using these enzymes and based on the formation of an isobutanol phase at sufficiently high concentration and with continuous removal of the organic phase, as shown by the reactor in the background. More information can be found in the Research Article by V. Sieber and co-workers (DOI: 10.1002/cssc.202501120).

[Cover]
Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber
ChemSusChem 2025, 18, 0. Read article.

The Cover Feature shows a sustainable recycling strategy for poly(ethylene terephthalate) (PET), employing the biobased solvent dihydrolevoglucosenone (Cyrene) both as a dissolution medium and as co-solvent for alkaline hydrolysis. This approach enables efficient PET regeneration and rapid hydrolysis under mild conditions, yielding high-purity PET or terephthalic acid (TPA). More details are available in the Research Article by L. Wang and co-workers (DOI: 10.1002/cssc.202501352).

[Cover]
Lulu Deng, Hailong He, Zhonghao Chen, Yao Meng, Lei Wang
ChemSusChem 2025, 18, 0. Read article.

A ternary metal catalyst system based on Pd/C, Pt/C, and Ru/C is found to be highly effective and robust for oxidizing alcohols to carboxylic acids using molecular oxygen. Combining the catalytic oxidation system with continuous flow, the conversion of 5-hydroxymethylfurfural (HMF) into 2,5-furandicarboxylic acid (FDCA), a bioplastics precursor, is successfully achieved on a scalable level.

[Research Article]
Mamoru Hyodo, Yusuke Takahashi, Yiyue Yao, Kinryo Cho, Takahide Fukuyama, Ilhyong Ryu
ChemistryEurope, https://doi.org/10.1002/ceur.202500246. Read article.

Low-temperaturefluorine (F) doping is employed to enhance the oxygen evolution reaction (OER)activity of CoFe spinel oxides. F-doping slightly reduces the valence state of Cowithout affecting morphology, leading to improved OER activity. Theseresults demonstrate that tuning the electronic structure of metal cations viaF-doping is a promising strategy for designing highly active spinel oxidecatalysts.

[Research Article]
Kazuyuki Iwase, Masaki Ohtaka, Ryoga Kato, Yoshiyuki Gambe, Takaaki Tomai, Itaru Honma
ChemCatChem, https://doi.org/10.1002/cctc.202501456. Read article.

Systematic control over coordination environments and subcomponent sequences enabled the formation and stabilization of trefoil perplexanes and trefoil tetrahedral knotted cages. Peripheral crosslinkers diminished framework stability to tune host-guest behavior and dynamic exchange, while mechanical entanglement modulated self-sorting and guest binding, offering routes to future functional designs.

[Research Article]
Dr. Yuchong Yang, Sabrina Y. Hu, Dr. Tanya K. Ronson, Paula C.P. Teeuwen, Dr. Sudhakar Gaikwad, Dr. Andrew W. Heard, Prof. David J. Wales, Prof. Jonathan R. Nitschke
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202519491. Read article.

Modular design of PTzBI-dF-Si balances solubility and aggregation in o-xylene, enabling fibrillar morphologies and mechanically robust stretchable organic solar cells.

[Research Article]
Xuanang Luo, Xinrui Liu, Youran Lin, Mingke Li, Zhiyuan Yang, Zhihui Xiong, Yang Wang, Dr. Feng Peng, Prof. Wenkai Zhong, Prof. Ning Li, Prof. Lei Ying
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202514985. Read article.

Cucurbit[6]uril-anchored copper (CB[6]-Cu) is reported as a stable single-site catalyst, achieving a 95.39% Faradaic efficiency for C2H4 at 300 mA cm−2 in electrocatalytic acetylene hydrogenation (EAH). The single-Cu-site and adjacent cavity structure facilitates optimal reactant coverage and disrupted hydrogen bonding, suppressing side reactions. The general applicability of this strategy is shown with CB[6]-Co for hydroxylamine synthesis.

[Research Article]
Yichen He, Fanpeng Chen, Dr. Bo-Hang Zhao, Dr. Chuanqi Cheng, Prof. Bin Zhang
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202518663. Read article.

While polymorphs I contain C2-symmetric enantiomers with pronounced azine twists and disrotatory phenyl twists, the acetophenone azine molecules in the new polymorphs II are Ci-symmetric with trans azine moieties and conrotatory phenyl twists. The three polymorphs II exemplify the new Paradigm IV for the supramolecular architectures of “laterally offset diarenes” and result in “shiplap/flat” idioteloamphiphile monolayers (IAMs).

[Research Article]
Harmeet Bhoday, Kaidi Yang, Steven P. Kelley, Rainer E. Glaser
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202500713. Read article.

The prebiotic reaction toward the Wöhler-RNA, a Proto-RNA-candidate, using aldehydes and biuret or triuret results in a mixture of the α- and β- furanosides and pyranosides. Investigation of the interconversion of these isomers shows different reactivity and stability of the biuret and triuret analogues as well as between the corresponding furanosides and pyranosides.

[Research Article]
Nathalie J. Kurrle, Dr. Maximilian Bechtel, Nathalie Hampel, Prof. Dr. Oliver Trapp
ChemSystemsChem, https://doi.org/10.1002/syst.202500046. Read article.

Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed-shell and open-shell systems, expanding reactivity and enabling innovative design strategies.

[Review]
Jaspreet Kaur, Joshua P. Barham
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502075. Read article.

Oxygen evolution reaction (OER), hindered by sluggish kinetics and intricate catalytic mechanisms, remains a key bottleneck in water splitting. In this work, selectively doping single-atomic Ir into NiMoO4 enables a synergistic adsorbate evolution mechanism and lattice oxygen mechanism (AEM-LOM), achieving superior performance: low overpotential (253 mV at 10 mA cm−2), remarkable stability (>1000 h), and practical applicability in water electrolyzers.

[Research Article]
Jinli Zhu, Xuebing Peng, Mi Guo, Yuhang Liu, Prof. Dongliang Chao, Prof. Daqiang Gao, Prof. Laiquan Li
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202516903. Read article.

Mono- and biphasic semihydrogenation of alkynes is catalyzed by water-dispersed palladium nanoparticles of various size, shape, and surface coatings at 1 and 50 bar hydrogen pressure. Spherical nanoparticles of 5 nm diameter were most efficient. Ultrasmall nanoparticles (2 nm) showed an increase in metallic character due to reduction by hydrogen during catalysis.

[Research Article]
Niklas Kost, Florian Lehmann, Rui Guo, Kateryna Loza, Marc Heggen, Thomas Seidensticker, Matthias Epple
ChemCatChem, https://doi.org/10.1002/cctc.202501164. Read article.

Photoconversion of phytochrome causes structural alterations in the chromophore binding pocket, associated with local electric field changes, which are analyzed by experimental and theoretical methods. The field changes propagate to the distant tongue region of the protein. Magnitude of the field changes may be an important factor contributing to the functionally essential secondary structure transition of the tongue.

[Research Article]
Mariafrancesca La Greca, Anh Duc Nguyen, Anastasia Kraskov, Norbert Michael, Luisa Sauthof, Manal Ebrahim, Sagie Katz, Johannes von Sass, Oan Tu Hoang, Nediljko Budisa, Patrick Scheerer, Ramona Schlesinger, Maria Andrea Mroginski, Peter Hildebrandt
ChemPhysChem, https://doi.org/10.1002/cphc.202500595. Read article.

A comprehensive investigation of laser-induced covalent patterning, defunctionalization, and refunctionalization of single-layer graphene with aryl diazonium salts is reported. Scanning Raman microscopy verifies spatial control, while systematic variation of laser parameters and substituent effects highlights the versatility of the method. The demonstrated “write-erase-rewrite” capability establishes a robust platform for micrometer-scale fabrication of complex, functionalized graphene architectures.

[Research Article]
Johanna Krüger, Tamara Nagel, Bowen Yang, Dr. Frank Hauke, Prof. Andreas Hirsch
Chemistry ? A European Journal 2025, 31, 0. Read article.

Powdered elemental bismuth in water forms 2D bismuth oxycarbonate nanosheets under high shear in a rapidly rotating tube housed in a vortex fluidic device, without the need of surfactants or other excipients, with uptake of atmospheric carbon dioxide.

[Research Article]
Fayed Abdullah Alrashaidi, Jason R. Gascooke, Mohammed Z. Asiri, Abigail K. Mann, Ashley Slattery, Jonathan A. Campbell, Youhong Tang, Colin L. Raston
Chemistry ? A European Journal 2025, 31, 0. Read article.