By integrating peptide-mediated protease activation and aptamer-directed target recognition with DNA hybridization chain reaction, an orthogonal amplification circuit was developed for cancer-selective PD-L1 imaging. The spatially controlled imaging of membrane PD-L1 enables pre-treatment assessment of tumor responses to immune checkpoint blockade therapy in vivo.

[Research Article]
Bo Wu, Xiulin Yi, Prof. Jian Zhao, Prof. Lele Li
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202520284. Read article.

A unified framework for designing robust cathode interphases is established by elucidating the TM-O hybridization (Δδ) and interfacial bonding strength (ICOHP). Leveraging this principle, NFA additive enables stable cycling of high-voltage graphite||LCO and graphite||NMC811 cells.

[Research Article]
Di Lu, Ruhong Li, Ling Lv, Baochen Ma, Shuoqing Zhang, Haikuo Zhang, Yiqiang Huang, Menglu Li, Xinyi Fu, Lixin Chen, Tao Deng, Xiulin Fan
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202518546. Read article.

Guided by pH-regulated structural transformation, two selenium-containing polyoxometalates, NMSeO-5 and NMSeO-6, were synthesized. A reversible ring-opening/closing process dramatically boosts their nonlinear optical properties, with SHG intensity increasing from 0.07 × to 10 × that of KDP. Supported by DFT calculations, the acid-promoted mechanism reveals the construction pathway of POMs and provides a general strategy to advance SHG performance of POM-based materials.

[Research Article]
Wei Zeng, Jing Zhang, Yao Tian, Prof. Hongmei Zeng, Prof. Zhien Lin, Prof. Liujiang Zhou, Prof. Kang Min Ok, Prof. Guohong Zou
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202520861. Read article.

A detailed mechanism supported by kinetic experiments, density functional theory (DFT) calculations, and X-ray crystallography is proposed for the chemo-, regio-, and stereoselective hydroboration of 1,3-enynes. Hydrocupration was determined to be the turnover-limiting step and essential for selectivity. An off-cycle, cyclic CuHBpinOAc complex is proposed to explain a positive fractional rate order in catalyst.

[Research Article]
Farshad Shiri, Nicklas W. Buchbinder, Andrew D. Bage, Reilly Gwinn, Carla Slebodnick, Webster L. Santos, Zhenyang Lin
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202501027. Read article.

Exploring the reactivity of the trivalent U(NHDIPP)5K2(THF)4 (1) leads to the formation of uranium imido complexes. Treating 1 with 18c6 causes spontaneous oxidation and the formation of [U(NDIPP)(NHDIPP)4][K(18c6)(THF)]2 (2). Oxidation of 1 or 2 results in the formation of U(NDIPP)2(NHDIPP)2 (3). This species is in equilibrium with the previously established U(NDIPP)3 and is trapped sterically or electronically.

[Research Article]
Kelly L. Gullett, Nickolas H. Anderson, MacKenzie C. Weaver, Landon O. King, Matthias Zeller, Suzanne C. Bart
ChemistryEurope, https://doi.org/10.1002/ceur.202500290. Read article.

We introduce the strategy of metal-catalyzed nitrene transfer for the formation of carbon-nitrogen bonds onto polybutadienes as polyolefin models. This post-functionalization methodology is not only efficient but also provides the control of the degree of functionalization. The latter nicely correlates with polymer properties such as the Tg. The process occurs without affecting the polymer structure, with no chain scission nor cross-linking side reactions.

[Communication]
Jorge Pérez-Ruíz, Dr. Manuel R. Ramírez, Christian Rentero, Dr. Valentina Sessini, Prof. Dr. Marta E. G. Mosquera, Prof. Dr. M. Mar Díaz-Requejo, Prof. Dr. Pedro J. Pérez
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202522659. Read article.

This work presents a defect-site activation strategy, in which anchoring Ir single atoms onto the highly strained defects of Pd metallene generates synergistic PdIr sites, leading to a dramatic enhancement in the ethanol oxidation reaction.

[Research Article]
Wenbo Li, Mengyue Gao, Zhen Jiang, Cheng Han, Yanyan Jia, Kuan-Wen Wang, Sheng Dai
ChemistryEurope, https://doi.org/10.1002/ceur.202500379. Read article.

This review summarizes the main factors affecting Fe-N-C catalysts for ORR: activity depends on active site structure, electronic configuration, and porosity, while stability is limited by metal leaching, carbon degradation, and inactive phase formation. Strategies like porosity engineering, dual-metal doping, protective encapsulation, advanced synthesis, and post-treatments are discussed to design highly active and durable catalysts.

[Review]
Mudassar Maqsood, Lebin Cai, Samona Zahid, Zhuangzhi Sun, Jianrui Zhang, Bao Yu Xia, Yaqiong Su
ChemistryEurope, https://doi.org/10.1002/ceur.202500279. Read article.

This review summarizes the current state of stereoselective epoxide polymerization, focusing especially on the past 10 years. Polymerization mechanisms, catalyst design strategies (both organometallic and metal-free), and applications of stereocontrolled polyethers are discussed, including their use as thermoplastic materials or regarding interfaces and self-assembly.

[Review]
Teo Borst, Stefan Naumann
ChemPlusChem, https://doi.org/10.1002/cplu.202500540. Read article.

Reacting 1-hydridosilatrane with triphenylcarbenium hexachloridoantimonate in acetonitrile solution and in the presence of 4-dimethylaminopyridine combines the world of silatranes with the world of carbenes, giving an unprecedented carbene-type antimony pentachloride complex. This finding offers a new playground for exciting new chemistry.

[Research Article]
David Mroß, Matthias Mawick, Lyuba Iovkova, Dieter Schollmeyer, Serhiy Demeshko, Viatcheslav Jouikov, Norbert Krause, Klaus Jurkschat
ChemistryEurope, https://doi.org/10.1002/ceur.202500197. Read article.

In summary, a visible light-driven redox coupling system is developed. As a trifunctional promoter, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) facilitates both the 1,2,3,4-tetrahydroisoquinoline (THIQ) oxidation by promoting the departure of electron/proton and the CO2 reduction by forming [DBUH]+[THIQ-CO2]-. This dual-promoting effect ensures redox-balanced conversion and enables preparation of high-value products.

[Research Article]
Xiangyang Yao, Wen-Jun Xie, Liqi Qiu, Liang-Nian He
ChemSusChem, https://doi.org/10.1002/cssc.202501750. Read article.

This review systematically summarizes product categories of electrocatalytic CO2 reduction from C1 to C2+ compounds, highlights strategies for steering selectivity toward ethylene/ethanol and C3 products. Moreover, it discusses methods to enhance efficiency, including suppressing hydrogen evolution, catalyst design, electrolyte effects, and reactor integration. Key challenges and techno-economic barriers are finally outlined.

[Review]
Xingqun Li, Junjie Yuan, Zhongqiu Wu, Han Zhang, Yong Li, Quan Zhang, Hui Xu
ChemSusChem, https://doi.org/10.1002/cssc.202501842. Read article.

The Front Cover presents polymorphic zinc-bound amyloid-β (Aβ) dimer models, derived from an extensive computational study of the molecular basis of zinc-induced Aβ primary nucleation. By revealing how zinc ions influence Aβ dimer structure and stability, the Research Article by K. Abramov Harpaz and Y. Miller (DOI: 10.1002/ejic.202500331) provides new insights into the mechanisms driving early aggregation events in Alzheimer’s disease, offering a molecular framework for future therapeutic strategies.

[Cover]
Karina Abramov Harpaz, Yifat Miller
European Journal of Inorganic Chemistry 2025, 0. Read article.

The Front Cover shows a microfluidic chip that was used in an enzyme engineering approach utilizing microdroplet-based UHTS to optimize an aldehyde dehydrogenase towards higher temperature stability and solvent tolerance. The optimized enzyme was then applied as part of a multi-enzyme cascade as indicated by the circle of enzyme structures above the chip. The ultimate goal is a continuous process for the conversion of glucose into isobutanol in a two-phase system using these enzymes and based on the formation of an isobutanol phase at sufficiently high concentration and with continuous removal of the organic phase, as shown by the reactor in the background. More information can be found in the Research Article by V. Sieber and co-workers (DOI: 10.1002/cssc.202501120).

[Cover]
Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber
ChemSusChem 2025, 18, 0. Read article.

The Cover Feature shows a sustainable recycling strategy for poly(ethylene terephthalate) (PET), employing the biobased solvent dihydrolevoglucosenone (Cyrene) both as a dissolution medium and as co-solvent for alkaline hydrolysis. This approach enables efficient PET regeneration and rapid hydrolysis under mild conditions, yielding high-purity PET or terephthalic acid (TPA). More details are available in the Research Article by L. Wang and co-workers (DOI: 10.1002/cssc.202501352).

[Cover]
Lulu Deng, Hailong He, Zhonghao Chen, Yao Meng, Lei Wang
ChemSusChem 2025, 18, 0. Read article.

Low-temperaturefluorine (F) doping is employed to enhance the oxygen evolution reaction (OER)activity of CoFe spinel oxides. F-doping slightly reduces the valence state of Cowithout affecting morphology, leading to improved OER activity. Theseresults demonstrate that tuning the electronic structure of metal cations viaF-doping is a promising strategy for designing highly active spinel oxidecatalysts.

[Research Article]
Kazuyuki Iwase, Masaki Ohtaka, Ryoga Kato, Yoshiyuki Gambe, Takaaki Tomai, Itaru Honma
ChemCatChem, https://doi.org/10.1002/cctc.202501456. Read article.

While polymorphs I contain C2-symmetric enantiomers with pronounced azine twists and disrotatory phenyl twists, the acetophenone azine molecules in the new polymorphs II are Ci-symmetric with trans azine moieties and conrotatory phenyl twists. The three polymorphs II exemplify the new Paradigm IV for the supramolecular architectures of “laterally offset diarenes” and result in “shiplap/flat” idioteloamphiphile monolayers (IAMs).

[Research Article]
Harmeet Bhoday, Kaidi Yang, Steven P. Kelley, Rainer E. Glaser
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202500713. Read article.

The prebiotic reaction toward the Wöhler-RNA, a Proto-RNA-candidate, using aldehydes and biuret or triuret results in a mixture of the α- and β- furanosides and pyranosides. Investigation of the interconversion of these isomers shows different reactivity and stability of the biuret and triuret analogues as well as between the corresponding furanosides and pyranosides.

[Research Article]
Nathalie J. Kurrle, Dr. Maximilian Bechtel, Nathalie Hampel, Prof. Dr. Oliver Trapp
ChemSystemsChem, https://doi.org/10.1002/syst.202500046. Read article.

Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed-shell and open-shell systems, expanding reactivity and enabling innovative design strategies.

[Review]
Jaspreet Kaur, Joshua P. Barham
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502075. Read article.

Mono- and biphasic semihydrogenation of alkynes is catalyzed by water-dispersed palladium nanoparticles of various size, shape, and surface coatings at 1 and 50 bar hydrogen pressure. Spherical nanoparticles of 5 nm diameter were most efficient. Ultrasmall nanoparticles (2 nm) showed an increase in metallic character due to reduction by hydrogen during catalysis.

[Research Article]
Niklas Kost, Florian Lehmann, Rui Guo, Kateryna Loza, Marc Heggen, Thomas Seidensticker, Matthias Epple
ChemCatChem, https://doi.org/10.1002/cctc.202501164. Read article.