FTY720 (fingolimod, Gilenya) is a sphingosine 1-phosphate (S1P) receptor modulator that was approved in September 2010 by the USFDA as a first-line treatment for relapsing forms of multiple sclerosis (MS). There is preclinical evidence that in addition to decreasing infiltration of lymphocytes into the central nervous system (CNS), FTY720 may provide additional neuroprotection through modulation of cerebral S1P receptors. To further study the action of FTY720 in the CNS, Emmanuelle Briard, Yves Auberson, and colleagues at the Novartis Institutes for BioMedical Research in Basel, Switzerland, evaluated a series of iodinated FTY720 derivatives that could be used to study the drug’s brain distribution in patients using nuclear imaging techniques.
After extensive profiling, they identified 2-iodo-FTY720 (BZM055) as a close mimic of FTY720, having similar physicochemical properties and organ distribution, despite the addition of an iodine atom. They also showed that BZM055 is phosphorylated into its biologically active form at a similar rate to FTY720, retaining an affinity and selectivity for S1P receptors comparable to FTY720-phosphate, as well as similar brain penetration kinetics. [123I]BZM055 is currently being developed as a SPECT tracer for studying the pharmacokinetics and distribution of FTY720 in the human brain. In addition, and since FTY720 has been shown to accumulate in myelin sheaths, this tracer might also prove useful to image myelin in MS patients.
- BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution
E. Briard, D. Orain, C. Beerli, A. Billich, M. Streiff, M. Bigaud, Y. P. Auberson,
ChemMedChem 2011, 6(02).