Novel Anti-Influenza Drugs

Novel Anti-Influenza Drugs

Author: ChemViews

Neuraminidases (NAs) regulate interactions with the extracellular world including infection, immunity, and cell–cell adhesion. Many pathogens utilize their own NAs, making NA inhibitors an attractive target for drug discovery.

A potent inhibitor for Vibrio cholerae neuraminidase (VCNA) – one of the oldest and best studied NA involved in cholera
pathogenesis – has been developed by Hiroshi Hinou and colleagues, Hokkaido University, Japan. Mechanism-based labeling study revealed the presence of a potential target loop for VCNA inhibition. The results were then used to prepare a focused library of 187 compounds. A [2+3] cyclization (click reaction) was used to prepare derivatives of DANA (2,3-dehydro-N-acetylneuraminic acid).

A N-trifluoroacetyl derivative of DANA, FANA, was identified as a potential inhibitor along with DANA analogue modified at the C9 position (see below). Validation studies suggested that the 9-substitution group interacted hydrophobically with the target loop moiety, adding a noncompetitive inhibition property to the DANA skeleton.

VCNA has an active site very similar to that observed in influenza (Flu) NA and Salmonella NA, meaning this two-step strategy presents a new route for the design of structurally novel anti-influenza drugs.

Image: (c) Wiley-VCH


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