Direct Arylation of Unactivated Arenes

  • ChemPubSoc Europe Logo
  • Author: ChemViews
  • Published Date: 27 February 2011
  • Source / Publisher: Chemistry - A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Direct Arylation of Unactivated Arenes

Related Societies

Palladium, nickel, and copper have received much attention as catalysts for cross-coupling reactions that form new C–C bonds. Cobalt, on the other hand, is relatively unexplored as a cross-coupling catalyst despite its lower toxicity and lower cost. Similarly, unactivated arenes, such as benzene, are not often used due to their low reactivity.


Aiwen Lei and co-workers, Wuhan University, China, have shown that the direct arylation of unactivated benzene can be performed with cobalt. Inexpensive and easy to handle [Co(acac)3] was used with lithium bis(trimethylsilyl)amide as a base. The reaction showed high efficiency, even with unactivated arenes and without extra ligands, and led to various biaryl products in excellent yields. In addition, an intramolecular direct arylation was also performed.


Article Views: 3259

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)published by Wiley-VCH