2010 Trends in Biochemistry

2010 Trends in Biochemistry

Author: ChemViews/GDCh

Nachrichten aus der Chemie (the membership magazine of the GDCh) annually publishes trend reports in which authors spot and compile an overview of inspiring work and recent trends in the most important chemical disciplines.

ChemViews gives you an overview of the latest trend report, its authors and the literature collected.

Biochemistry 2010

  • Nucleotide modifications: Precious for fundamental research and therapeutic applications.
    Andres Jäschke, Ronald Micura, Arnold Grünweller, Roland Hartmann, Mark Helm
  • Synthetic biology: What is it, what are its perspectives and which techniques are employed?
    Wolfgang Liebl, Nediljko Budisa, Lars Merkel
  • Combinatorial biosynthesis: Beyond polyketides.
    Uschi Sundermann, Susanna Kushnir, Frank Schulz

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Authors

Andres Jäschke, born 1962, has held a chair in pharmaceutical chemistry at the University of Heidelberg, Germany, since 2002. He studied chemistry at the Humboldt University of Berlin, Germany, and did his PhD under the supervision of Dieter Cech in 1993. From 1993 to 1995, he was a post-doc under Alexander Rich at MIT, USA. In 2000, he habilitated in bioorganic chemistry at the Free University of Berlin, Germany.

His research interests encompass catalytic and regulatory nucleic acids, molecular switches as well as hybrid catalysts.

Ronald Micura, born 1970, has been a professor of organic chemistry at the University of Innsbruck, Austria, since 2004. He studied engineering economics/technical chemistry at the University of Linz, Austria, where he did his PhD in 1995. After a post-doc period from 1996 to 1998 at the Swiss Federal Institute of Technology Zürich and at the Scripps Research Institute, USA, he habilitated in organic chemistry at the University Innsbruck in 2002.

His field of research is the chemical biology of nucleic acids.

Roland K. Hartmann, born 1956, has been a C4 professor at the Institute for Pharmaceutical Chemistry of the University of Marburg, Germany, since 2003. He studied biochemistry at the Free University of Berlin. After his PhD and Habilitation (1993) at the faculty of chemistry of the Free University of Berlin, he switched to the Institute of Biochemistry of the University of Lübeck, Germany, in 1995.

His research interests are catalytic and regulatory RNA molecules.

Arnold Grünweller, born 1964, has been an academic senior councilor (Akademischer Oberrat) in the group of Hartmann at the University of Marburg since 2004. He studied biology at the University of Gießen, Germany. Following his PhD in 1997 at the Institute of Medicinal Molecular Biology of University of Lübeck, he worked as a post-doc at the Max Planck Institute of Molecular Genetics in Berlin and at the Institute of Biochemistry of the Free University Berlin.

His research interests concern the areas of regulatory RNA molecules, modified nucleic acids and the regulation of chromatin structure.

Mark Helm, born 1969, has been a professor of pharmaceutical/medicinal chemistry at the University of Mainz, Germany, since 2009. He habilitated in 1999 in molecular biology at the University of Strasburg, France, followed by post-doc periods at the California Institute of Technology, USA, and the Free University of Berlin, Germany. Afterwards, he was a research group leader in the department of chemistry at the Institute of Pharmacy and Molecular Biotechnology of the University of Heidelberg, where he habilitated in 2008 in the subjects pharmaceutical chemistry and biochemistry.

His research areas: structural dynamics of RNA, uptake and intracellular distribution of siRNA ribonucleotide modifications, RNA bioconjugates.


Wolfgang Liebl
, born 1959, holds a chair in microbiology at the Technical University of Munich (TU Munich), Germany. He studied biology with microbiology and did his PhD in microbiology at TU Munich. After a research period at MIT in Cambridge, Massachusetts, USA, from 1986 to 1987 and his habilitation at TU Munich, he accepted an appointment to the University of Göttingen, Germany, in 1997, where he headed the department for Genomic and Applied Microbiology. In 2008, he retuned to TU Munich.

His research interest are applied microbiology, in particular enzymatic activities involved in the degradation of microbial polysaccharides; extremophile microorganisms; and physiology and genetics of biotechnical relevant bacteria.

Nediljko Budisa is leader of the working group biocatalysis at the Technical University Berlin. He received his PhD 1997 in the group of Robert Huber at the Max Planck Institute for Biochemistry in Martinsried, Germany. From 1997 to 2010, he worked at the Max Planck Institute for Biochemistry, initially as a post-doc, and later as a private lecturer and independent group leader. His research is supported by the BioFuture Program of the German Federal Ministry of Education and Research.

His research focuses on the heart of synthetic biology and shall create a solid basis for the laboratory evolution of synthetic life forms on the basis of new chemical components.


Lars Merkel
has been a research assistant in the specialist area of biocatalysis at the Technical University Berlin since 2010. He studied chemistry at the Technical University Clausthal, Gremany, and drew up his diploma thesis in the working group of Andreas Schmidt in organic chemistry. For his PhD he switched to the group of Nediljko Budisa at the Max Planck Institute for Biochemistry and the Technical University of Munich, where he completed his PhD in 2008.

Uschi Sundermann, born 1983, has been working toward her PhD in the working group of Frank Schulz since 2008 and is a member of the International Max Planck Research School on Chemical Biology in Dortmund, Germany. From 2003 to 2008, she studied biotechnology/chemical engineering at the University of Applied Sciences Emden/Leer, Germany. In addition, she has a BSc in toxicology from the Athlone Institute of Technology, Ireland.

Susanna Kushnir, born 1966, has been a research assistant in chemical biology at the faculty of chemistry of the Technical University of Dortmund since 2009. She did her PhD in 1996 under the supervision of Viktor Fedorenko at the Ukrainian Ivan Franko National University of Lviv, where she stayed until 2000 as a research assistant in the department of Genetics and Biotechnology. Thereafter, she moved to a post-doc position at the Hans-Knöll-Institute and the Institute for Molecular Biotechnology in Jena, Germany. In 2003, she went to work at the Max-Planck-Institute of Molecular Physiology in Dortmund.

Frank Schulz, born 1979, is the Beilstein-Foundation professor for bioorganic chemistry at the Technical University of Dortmund. He did his PhD in the working group of Manfred T. Reetz at the Max Planck Institute für Kohlenforschung in Mülheim, Germany. In 2007, he went to work as a post-doc in the working group of Peter F. Leadlay at the University of Cambridge, UK. At the end of 2008, he came back to Germany to establish his own working group.

His group is concerned with fermentative and chemoenzymatic syntheses of natural products.

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