Tumor Imaging with Polymer Dots

  • ChemPubSoc Europe Logo
  • Author: Angewandte Chemie International Edition
  • Published Date: 13 March 2011
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Tumor Imaging with Polymer Dots

The design of bright/fluorescent probes with biologically benign materials is highly desirable for in vivo clinical purposes.

Working with colleagues from China and the USA, Daniel Chiu and co-workers have made an important advance for in vivo imaging based on new organic nanoparticles. They used semiconducting polymer dots—which have exceptional brightness, are nontoxic, and have broad absorption in the visual region with efficient emission in the red region—that were conjugated to a peptide chlorotoxin to specifically target brain tumors in a transgenic mouse model (see figure).

These new bioconjugates are promising candidates as probes for clinical diagnostics.

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