Palladium-Catalyzed Aminocarbonylation

  • ChemPubSoc Europe Logo
  • Author: Andrei Dragan
  • Published Date: 02 February 2017
  • Source / Publisher: Chemistry – An Asian Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Palladium-Catalyzed Aminocarbonylation

Palladium-catalyzed aminocarbonylation reactions between aryl halides and amines generally require toxic CO gas as the carbonyl source. Carbon monoxide-free palladium-catalyzed aminocarbonylation reactions using various CO surrogates have become an attractive research goal.


Chul-Ho Jun, Yonsei University, Korea, and colleagues developed a method for the synthesis of amides and phthalimides from aryl halides. They used carbodiimides and formic acid as the carbonyl source, and palladium(II) acetate together with an imidazole ligand as the catalyst.


This process is the first example of an in situ formation of CO from formic acid and a carbodiimide in the presence of Pd(OAc)2. The reaction provided the aminocarbonylation products (amides and phthalimides) of aryl halides along with their isocyanate co-products in a simple and efficient manner.


 

Article Views: 2220

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH