Arene Amination Using Photoredox Catalysis

  • Author: Andrei Dragan
  • Published Date: 04 March 2017
  • Source / Publisher: Asian Journal of Organic Chemistry/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Arene Amination Using Photoredox Catalysis

Photoredox-catalyzed dehydrogenative cross-coupling reactions are valuable approaches for the direct amination of arenes. Aromatic amines are highly important as they are found in many natural products, pharmaceuticals, and agrochemicals, and are used in many organic syntheses. Transition-metal-catalyzed cross-coupling reactions are very common, but this approach requires pre-functionalized arenes.

Ganesh Pandey, Centre of Bio-Medical Research (CBMR), Lucknow, India, and colleagues have developed a visible-light photoredox-catalyzed aryl C(sp2)–H amination (product example pictured). The team used different amine derivatives such as imidazole, triazole, and tetrazole in the presence of Ru(bpy)3Cl2 (bpy = 2,2'-bipyridyl) as a photoredox catalyst and Selectfluor® as an oxidative quencher.

The researchers were able to selectively aminate a broad range of aromatic compounds in a selective manner and with good yields. According to the team, the developed cross-coupling reaction of aromatic compounds and nitrogen heterocycles is quite general in scope and can be used on aryl substrates that contain oxidizable groups, such as aldehydes, alcohols, and alkenes.


Article Views: 2784

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH