Photoactive Iridium Complexes for Cancer Therapy

  • Author: Angewandte Chemie International Edition
  • Published Date: 17 November 2017
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Photoactive Iridium Complexes for Cancer Therapy

Photochemotherapy is attractive and offers the prospect of localized attacks on cancer cells, whilst sparing normal tissue. It can generate highly reactive chemical species, which bypass cell-resistance mechanisms.


Peter B. O'Connor, Peter J. Sadler, University of Warwick, Coventry, UK, Hui Chao, Sun Yat-Sen University, Guangzhou, China, and colleagues have designed photoactive metal coordination complexes with optimized properties for such therapies. The researchers synthesized octahedral organoiridium(III) complexes, which are highly stable in the dark. Time-dependent density functional theory (TD-DFT) calculations showed how the choice of chelating ligands controls light absorption.


The complexes' excited states are long-lived and emit red light when irradiated with blue light. They generate highly reactive singlet oxygen from ground-state triplet oxygen efficiently. For this process, not only blue light can be used, but also red light (which penetrates more deeply into tissues), as short two-photon laser pulses.


The team demonstrated the high selective potency of these photoactivated iridium complexes toward lung cancer compared to normal lung cells, including 3D spheroid models of tumors. The induction of oxidation of specific histidine residues in the key cellular proteins aldose reductase and heat shock protein 70 in cancer cells was detected using ultra-high resolution mass spectrometry.


 

Article Views: 3067

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH