A Dual-Channel Microreactor

A Dual-Channel Microreactor

Author: Angewandte Chemie International Edition

The development of a safe method for the production and subsequent use of toxic, sensitive, and explosive volatile chemicals or gaseous intermediates in organic synthesis is always a challenge.

Dong-Pyo Kim and co-workers at Chungnam National University, South Korea, have constructed a dual-channel microreactor that generates diazomethane (CH2N2) an extremely toxic, carcinogenic, odorless, and explosive yellow gas, ready for use in a variety of reactions.

Not only is diazomethane generated in situ but it is also separated and reacted in a safe manner using their special set up (see figure; Dizald is the diazomethane precursor). Thus “dry” diazomethane diffuses through a poly(dimethylsiloxane) membrane into a second channel where the reagent is consumed.

Images: (c) Wiley-VCH

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