Potent Anticancer Diazido Pt(IV) Prodrug

  • ChemPubSoc Europe Logo
  • Author: Chemistry - A European Journal
  • Published Date: 25 February 2018
  • Source / Publisher: Chemistry - A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Potent Anticancer Diazido Pt(IV) Prodrug

Related Societies

Metal-based photoactivated chemotherapy (PACT) against cancer can provide temporal and spatial control to reduce off-target side effects and battle inherent and acquired resistances. PACT candidates can destroy cancer cells through their metal core and/or released ligand species. Studying their underlying photophysical and photochemical mechanisms of action remains challenging.


Peter J. Sadler, University of Warwick, UK, Bayden R. Wood, Monash University, Clayton, Australia, and colleagues have studied the potent diazido Pt(IV) PACT prodrug trans,trans,trans-[Pt(N3)2(OH)2(py)2] (py = pyridine). The team used infrared (IR) spectroscopy to follow the metal and ligand vibrations upon light activation, combined with transient electronic absorption and UV/Vis spectroscopy, mass spectrometry (MS), and theoretical calculations.


The results provide insights into the unusual reactivity of this prodrug: The team was able to identify trans-[Pt(N3)(py)2(OH/H2O)] as an intermediate and trans-[Pt(py)2(OH/H2O)2] as the final product upon light activation of the prodrug. These findings could help to understand the chemical and biological mechanism of the complexes anticancer activity. They also demonstrate the potential of vibrational spectroscopic techniques to study such metal complexes.


 

Article Views: 739

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH