Controlling Genes with Light

  • ChemPubSoc Europe Logo
  • Author: Ruben Ragg
  • Published Date: 12 June 2018
  • Source / Publisher: ChemBioChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Controlling Genes with Light

Related Societies

Sensory photoreceptors control adaptations to light in a variety of organisms. They serve as main targets in optogenetics, a recently developed technique that can be used for the reversible, non-invasive, and spatiotemporally precise manipulation of cellular physiology by light.


To achieve finely tuned control of light-responsive biological systems, Andreas Möglich and colleagues, University of Bayreuth, Germany, designed experimental protocols and hardware for the application of pulsed lighting. The team constructed a programmable matrix of light‐emitting diodes (LEDs). The pulse frequency of intermittent light can be used as an additional input variable to light quantity and quality for controlling system output in optogenetics and photobiology. Pulsed illumination of a single color is enough to sequentially trigger the expression of several genes.


Optimized schemes for pulsed illumination could lead to a reduction of required light dose and allow the combination of several light-responsive circuits.


 

Article Views: 454

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH