Drug Release from Hydrogels Controlled with Light

  • ChemPubSoc Europe Logo
  • Author: Chemistry – A European Journal
  • Published Date: 31 August 2018
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Drug Release from Hydrogels Controlled with Light

Related Societies

Theoretically, steering biological processes and systems with light allows precise control without permanently contaminating the target. There is, however, one fundamental problem: most biomolecules are not sensitive to light (apart from their eventual degradation). Thus, artificial "adapters" are needed to transform light energy into biological functions. Many of these systems have the additional problem that they only respond to harmful UV light.


Zbigniew L. Pianowski and Johannes Karcher, Karlsruhe Institute of Technology, Germany, have created a light-sensitive biocompatible material that forms supramolecular hydrogels. The used hydrogelator is based on a photochromic (S)‐α‐amino acid, which was coupled to a protected (S)‐lysine. The resulting hydrogels can physically encapsulate various unmodified drug molecules. Upon irradiation with green (i.e., visible) light, the gels dissipate to fluid form and release the encapsulated drugs in their active form. This effect is due to a transition of the majority of the hydrogelator's molecules from the trans‐ to the cis‐isomer, which destabilizes the hydrogel's structure.


Using a gel loaded with antibiotics, the growth of bacterial cultures could be suppressed with green light. The developed gels could have applications in photopharmacology, for example, in the form of light-induced drug-releasing implants or, after microgel formulation, for controlled drug delivery systems delivered through the bloodstream.


 

Article Views: 504

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH