Fluorescent Antifungal Agents

  • ChemPubSoc Europe Logo
  • Author: Angewandte Chemie International Edition
  • Published Date: 26 November 2018
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Fluorescent Antifungal Agents

Fungal infections have been on the rise because of increasing numbers of people with suppressed or nonfunctional immune systems. One class of synthetic antifungal agents, cationic amphiphiles, have broad-spectrum and potent antifungal activity. How these molecules eradicate fungal cells, however, had not been fully understood so far.


Micha Fridman and colleagues, Tel Aviv University, Israel, have used fluorescent antifungal cationic amphiphiles (pictured) to study the effects of this type of compound on cells of disease-causing fungi. The team treated Candida yeast cells, considered the most common disease-causing fungal pathogen worldwide, with the fluorescent antifungal cationic amphiphiles and then imaged the cells.


The results revealed that the antifungal agents rapidly accumulate inside the cells and lead to changes in the structures of proteins and DNA. The team also discovered that the antifungal compounds disassemble the different intracellular compartments (organelles) inside the fungal cells, which leads to the eradication of the pathogen. According to the researchers, the intracellular effects of these agents must be considered when designing antifungals for clinical use, because they could also affect mammalian cells.


 

Article Views: 472

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH