Atom Transfer Radical Polymerization in Air

  • ChemPubSoc Europe Logo
  • Author: Angewandte Chemie International Edition
  • Published Date: 03 December 2018
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Atom Transfer Radical Polymerization in Air

Atom transfer radical polymerization (ATRP) allows the polymerization of a broad selection of monomers with control over the molecular weight, dispersity, and architecture. However, oxygen can poison the activators for ATRP. It can also quench chain growth by forming very stable peroxy radicals with the propagating chains. Therefore, ATRP is typically performed under air-free conditions or with an excess of reducing agents.


Krzysztof Matyjaszewski and colleagues, Carnegie Mellon University, Pittsburgh, USA, have used an enzymatic cascade to remove oxygen and to generate a steady flow of radicals, which are needed for the formation of activators. In this way, the team was able to trigger ATRP in air. After the complete removal of oxygen, the polymerization slowed down or stopped, which contrasts dramatically with conventional polymerizations.


The biocatalytic system (pictured) contains glucose oxidase (GOx), horseradish peroxidase (HRP), and a copper complex. In the presence of glucose and acetylacetonate (acac) as sacrificial substrates, a very stable copper tris(2-pyridylmethyl)amine complex is activated that controls radical polymerization. The team applied the procedure to the synthesis of protein-b-polymer and DNA-b-polymer bioconjugates, and to well-defined polymers and coatings under atmospheric conditions and at room temperature.


 

Article Views: 479

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH