Halogen-Mediated Transport through Cell Membranes

  • ChemPubSoc Europe Logo
  • Author: Chemistry – A European Journal
  • Published Date: 08 March 2019
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Halogen-Mediated Transport through Cell Membranes

The delivery of small molecules into cells is important, e.g., for therapeutic applications. Gaseous molecules such as oxygen and carbon dioxide or uncharged molecules such as water and ethanol can cross the plasma cell membrane by simple passive diffusion. However, larger molecules require specific membrane transporters and channel proteins for cellular delivery.


Govindasamy Mugesh and colleagues, Indian Institute of Science, Bangalore, have studied the transport of small organic molecules across plasma membranes. The team found that the introduction of iodine atoms into a series of fluorescent molecules (example pictured) remarkably enhances the cellular uptake. The process was monitored by observing the fluorescence intensities. Using two iodine atoms, the cellular uptake can be increased to more than 95 % in mammalian cells. The nature of the fluorescent group does not play a major role in the cellular uptake when iodine atoms are present.


The researchers showed that the halogen compounds are transported into the cells by the thyroid hormone-specific monocarboxylate transporter 8 (MCT8). The iodine serves as a recognition unit for the membrane transporter. This study provides a new strategy for enhancing the uptake of organic molecules by mammalian cells, which could be used for studying membrane activity, cellular functions, and drug delivery.


 

Article Views: 444

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH