Two Spectroscopies in One

  • Author: Angewandte Chemie International Edition
  • Published Date: 08 November 2020
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH GmbH
thumbnail image: Two Spectroscopies in One

Vibrational Raman optical activity (ROA), a modern variant of chiral spectroscopy, is particularly useful for biomolecular studies. Researchers have noticed that some chiral molecules can induce an ROA signal in achiral solvents. Surprisingly, the effect of this "transferred" chirality is often bigger than that of the molecule itself.

Yunjie Xu, University of Alberta, Edmonton, Canada, Josef Kapitán, Palacký University, Olomouc, Czech Republic, Petr Bouř, Academy of Sciences, Prague, Czech Republic, and colleagues have performed an analysis based on light-scattering theory and dedicated experiments to provide a more complete understanding of this chirality transfer. The results indicate that an interference of electronic circular dichroism (ECD) with the polarized Raman scattering is responsible for the effect. To confirm this interference of ECD and ROA, the team analyzed ROA spectra for model chiral nickel and copper complexes in a chloroform solvent. The chiral complexes induced the expected ROA effect in the solvent.

The effect seems to be fairly general for achiral organic solvents and solutes such as chiral transition-metal complexes of nickel or copper. It remains to be seen how this new phenomenon, the interference of circular dichroism and ROA, can be used practically. The researchers are confident that, as the effect is strong, it will boost the sensitivity of chiral spectroscopy and might have applications in imaging. It is also relevant for the construction of better ROA spectrometers that use ultraviolet light for excitation.



Article Views: 2620

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH