Glutathione Peroxidase-Mimicking Nanozymes

  • Author: Angewandte Chemie International Edition
  • Published Date: 27 October 2020
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH GmbH
thumbnail image: Glutathione Peroxidase-Mimicking Nanozymes

Nanozymes are enzyme-mimicking nanomaterials. They can have advantages over both natural enzymes and conventional artificial enzymes. While a few glutathione peroxidase (GPx)-mimicking nanozymes have been developed, such nanozymes have rarely been explored for use in therapy. Glutathione peroxidase plays an important role in maintaining the metabolic balance of reactive oxygen species (ROS), which can be relevant for diseases such as cancer, inflammation, and cardiovascular issues.


Hui Wei, Nanjing University, China, and colleagues have developed a ligand-engineering strategy to tune the GPx-mimicking activity of a metal–organic framework (MOF) nanozyme. The team modulated the GPx-mimicking activities of vanadium-based MIL-47(V) MOFs by varying the substitution of their terephthalate ligand, using F, Br, NH2, CH3, or OH groups. The synthesis of MIL-47(V)-X MOFs was carried out via a microwave method.


The GPx-mimicking catalytic activities of the nanozymes were investigated using an assay in which the nanozyme catalytically couples the reduction of H2O2 to the oxidation of glutathione (GSH) to glutathione disulfide (GSSG). MIL-47(V)-NH2 exhibited the highest activity among the resulting isostructural MOFs. In vivo experiments using mouse models showed an excellent antioxidation ability for MIL-47(V)-NH2, which alleviated the inflammatory response for both ear inflammation and colitis. This work shows that a GPx-mimicking nanozyme alone can be used in anti-inflammation therapy.


 

 

Article Views: 2799

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH